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Cellosaurus HT-29 (CVCL_0320)

[Text version]
Cell line name HT-29
Synonyms HT 29; HT29
Accession CVCL_0320
Resource Identification Initiative To cite this cell line use: HT-29 (RRID:CVCL_0320)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: JFCR39 cancer cell line panel.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: NCI-60 cancer cell line panel.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 809.
Population: Caucasian.
Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
Doubling time: 1.2 days (PubMed=6445228); 36.93 hours (PubMed=25944804); 24 hours (PubMed=25984343); 24 hours (PubMed=23546019); 21.87 +- 0.12 hours (PubMed=32927768); ~24 hours (CLS=300215); ~40-60 hours (DSMZ=ACC-299); 19.5 hours (NCI-DTP=HT-29); ~23 hours (PBCF).
Karyotypic information: Hypertriploid karyotype.
Microsatellite instability: Stable (MSS) (PubMed=9000147; PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746; Sanger).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Extracellular vesicles proteome analysis.
Omics: Deep phosphoproteome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Fluorescence phenotype profiling.
Omics: lncRNA expression profiling.
Omics: Metabolome analysis.
Omics: miRNA expression profiling.
Omics: N-glycan profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Caution: Indicated in PubMed=11921276 as originating from an adenocarcinoma of the rectosigmoid part of the intestine, but is only indicated in the oldest publication (DOI=10.1007/978-1-4757-1647-4_5) as a colon adenocarcinoma.
Misspelling: HCT29; GEO=GSM206503.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
HLA typing Source: PubMed=77569
Class I
HLA-AA*01/11,03
HLA-BB*12,17

Source: PubMed=15748285
Class I
HLA-AA*01,24
HLA-BB*35,44:03:01
HLA-CC*04
Class II
HLA-DPDPB1*04:01
HLA-DQDQB1*02,03:02
HLA-DRDRB1*04:02,07:01

Source: PubMed=26589293
Class I
HLA-AA*01:01,24:03
HLA-BB*35:01,44:03
HLA-CC*04:01,04:01

Source: CLS=300215
Class I
HLA-AA*01:01:01,24:03:01
HLA-BB*35:01:01,44:03:01
HLA-CC*04:01:01
Class II
HLA-DPDPB1*04:01
HLA-DQDQA1*02:01:01,03:01:01
DQB1*02:02:01,03:02:01
HLA-DRDRB1*04:02:01,07:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.57
Native American1.05
East Asian, North3.24
East Asian, South0
South Asian4.8
European, North26.11
European, South63.24
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_9556 (2474/90)CVCL_9557 (2957/90)CVCL_9558 (3051/80)
CVCL_0144 (ARO)CVCL_2011 (CX-1)CVCL_DH88 (HT-29 BR100)
CVCL_DH89 (HT-29 BR200)CVCL_DH90 (HT-29 BR300)CVCL_H252 (HT-29 HD3)
CVCL_H253 (HT-29 HD4)CVCL_H254 (HT-29 HD6)CVCL_H255 (HT-29 HD8)
CVCL_C1KN (HT-29 Y1-16)CVCL_C1KP (HT-29 Y1-4)CVCL_C1KQ (HT-29 Y1-7)
CVCL_8118 (HT-29-D4)CVCL_4Z22 (HT-29-D9)CVCL_6833 (HT-29-G)
CVCL_J256 (HT-29-Luc [JCRB])CVCL_C8XV (HT-29-Luc [Ubigene])CVCL_5J34 (HT-29-luc-D6)
CVCL_G077 (HT-29-M6)CVCL_6834 (HT-29-MTX)CVCL_5J00 (HT-29-Red-FLuc)
CVCL_0I27 (HT-29/5-FU)CVCL_0T66 (HT-29/5-FU/S)CVCL_Y178 (HT-29/ADM)
CVCL_LJ30 (HT-29/B6)CVCL_C9ER (HT-29/Cas9-hyg)CVCL_Y177 (HT-29/cDDP)
CVCL_DE12 (HT-29/cl.f8)CVCL_H269 (HT-29/CPT)CVCL_Y179 (HT-29/ETP)
CVCL_WV61 (HT-29/SN-38)CVCL_C3GK (HT-29_6244R)CVCL_WN77 (HT-29KM)
CVCL_EQ49 (HT-29R)CVCL_4V27 (HT-29R13)CVCL_5U94 (HT29 LM1)
CVCL_C764 (HT29-12B)CVCL_C765 (HT29-13G)CVCL_C763 (HT29-16E)
CVCL_5940 (HT29-18)CVCL_0323 (HT29-19A)CVCL_A3CP (HT29-5FU resistant (1 microMolar))
CVCL_A8P6 (HT29-5FU resistant (10 microMolar))CVCL_A8P9 (HT29-5M12)CVCL_A8Q0 (HT29-5M21)
CVCL_5J20 (HT29-luc2)CVCL_A8BX (HT29-Lucia AhR)CVCL_5949 (HT29-OxR)
CVCL_EQ23 (HT29-R)CVCL_2521 (HT29/219)CVCL_4V74 (HT29/L-OHP)
CVCL_C8V7 (HTFU)CVCL_8476 (HTOXAR3)CVCL_D6BR (HyCyte HT-29 KO-hCCAT2)
CVCL_E1LC (HyCyte HT-29 KO-hDCAF4)CVCL_E1LD (HyCyte HT-29 KO-hTIMM17B)CVCL_E3HK (HyCyte HT-29-Luc)
CVCL_6301 (KAK-1)CVCL_6302 (KAT-10)CVCL_6304 (KAT-4)
CVCL_0370 (KAT-5)CVCL_6305 (KAT-50)CVCL_6306 (KAT-7)
CVCL_L095 (KM20)CVCL_D889 (KM20L2)CVCL_YJ83 (LINTERNA HT-29)
CVCL_6310 (MRO)CVCL_7204 (MV-522)CVCL_M779 (RO-D81-1)
CVCL_D9WF (Ubigene HT-29 ESRP2 KO)CVCL_D9WG (Ubigene HT-29 ETHE1 KO)CVCL_D9WH (Ubigene HT-29 FKBP10 KO)
CVCL_D9WI (Ubigene HT-29 HDGF KO)CVCL_D9WJ (Ubigene HT-29 PIEZO1 KO)CVCL_D9WK (Ubigene HT-29 SELENBP1 KO)
CVCL_D9WL (Ubigene HT-29 SIRT3 KO)CVCL_D9WM (Ubigene HT-29 SQSTM1 KO)CVCL_2760 (WiDr)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0009004/48; ATCC=HTB-38; CCRID; CLS=300215; Cosmic-CLP=905939; DSMZ=ACC-299; ECACC=91072201; KCLB=30038; PubMed=11416159; PubMed=19372543; PubMed=25877200; PubMed=25926053; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO11,12
D1S165615,16
D2S44111
D2S133819,23
D3S135815,17
D5S81811,12
D7S82010
D8S117910 (AddexBio=C0009004/48; CLS=300215; DSMZ=ACC-299; PubMed=19372543; PubMed=25877200)
10,16 (ATCC=HTB-38; CCRID; PubMed=11416159; Technion Genomics Center)
D10S124814,16
D12S39118.3,21
D13S31711 (AddexBio=C0009004/48; CLS=300215)
11,12 (ATCC=HTB-38; CCRID; Cosmic-CLP=905939; DSMZ=ACC-299; ECACC=91072201; KCLB=30038; PubMed=19372543; PubMed=25877200; PubMed=25926053; Technion Genomics Center)
D16S53911,12
D18S5113
D19S43314
D21S1129,30
D22S104516
FGA20,22
Penta D11,13
Penta E14,16
TH016,9
TPOX8,9
vWA17,19

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/HT-29
https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
https://www.atcc.org/en/support/technical-support/faqs/htb-38-morphology-and-media
https://www.synapse.org/#!Synapse:syn31544471
https://strap.nci.nih.gov/celline_detail.php?sample_id=15
https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/HT29.html
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-32.html
https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-colorectal-adenocarcinoma-cell-line-ht-29
https://tcpaportal.org/mclp/
Publications

DOI=10.1007/978-1-4757-1647-4_5
Fogh J., Trempe G.L.
New human tumor cell lines.
(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.115-159; Springer; New York; USA (1975)

PubMed=1159834; DOI=10.1093/jnci/55.3.555
von Kleist S., Chany E., Burtin P., King M., Fogh J.
Immunohistology of the antigenic pattern of a continuous cell line from a human colon tumor.
J. Natl. Cancer Inst. 55:555-560(1975)

PubMed=72600
Sharma B.
In vitro immunization against human tumor cells with tumor cell fractions.
Cancer Res. 37:4660-4668(1977)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=864752; DOI=10.1093/jnci/58.6.1743
Marshall C.J., Franks L.M., Carbonell A.W.
Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas.
J. Natl. Cancer Inst. 58:1743-1751(1977)

PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x
Espmark J.A., Ahlqvist-Roth L., Sarne L., Persson A.
Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.
Tissue Antigens 11:279-286(1978)

PubMed=626984
Erickson L.C., Osieka R., Kohn K.W.
Differential repair of 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1- nitrosourea-induced DNA damage in two human colon tumor cell lines.
Cancer Res. 38:802-808(1978)

PubMed=468301; PMCID=PMC1457289
Trejdosiewicz L.K., Trejdosiewicz A.J., Ling N.R., Dykes P.W.
Growth enhancing property of human monocytes from normal donors and cancer patients.
Immunology 37:247-252(1979)

PubMed=6256643; DOI=10.1038/288724a0
Day R.S. 3rd, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A., Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D.
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.
Nature 288:724-727(1980)

PubMed=6445228
Kimball P.M., Brattain M.G.
Isolation of a cellular subpopulation from a human colonic carcinoma cell line.
Cancer Res. 40:1574-1579(1980)

PubMed=22282976; DOI=10.1093/carcin/1.1.21
Day R.S. 3rd, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A., Mattern M.R.
Human tumor cell strains defective in the repair of alkylation damage.
Carcinogenesis 1:21-32(1980)

PubMed=7017212; DOI=10.1093/jnci/66.6.1003
Pollack M.S., Heagney S.D., Livingston P.O., Fogh J.
HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.
J. Natl. Cancer Inst. 66:1003-1012(1981)

PubMed=7459858
Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=6220172
Dracopoli N.C., Fogh J.
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=6825208; DOI=10.1093/carcin/4.2.199
Yarosh D.B., Foote R.S., Mitra S., Day R.S. 3rd
Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.
Carcinogenesis 4:199-205(1983)

PubMed=6500159; DOI=10.1159/000163283
Gershwin M.E., Lentz D., Owens R.B.
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3472642; DOI=10.1016/0165-4608(87)90267-6
Chen T.-R., Drabkowski D.J., Hay R.J., Macy M.L., Peterson W.D. Jr.
WiDr is a derivative of another colon adenocarcinoma cell line, HT-29.
Cancer Genet. Cytogenet. 27:125-134(1987)

PubMed=3335022
Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=3349466
Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=2288877
Hafez M.M., Infante D., Winawer S.J., Friedman E.
Transforming growth factor beta 1 acts as an autocrine-negative growth regulator in colon enterocytic differentiation but not in goblet cell maturation.
Cell Growth Differ. 1:617-626(1990)

PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x; PMCID=PMC5918361
Takeshima E., Hamaguchi M., Watanabe T., Akiyama S., Kataoka M., Ohnishi Y., Xiao H.-Y., Nagai Y., Takagi H.
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
Jpn. J. Cancer Res. 82:1428-1435(1991)

PubMed=1937958; DOI=10.1002/ijc.2910490516
Lesuffleur T., Kornowski A., Luccioni C., Muleris M., Barbat A., Beaumatin J., Dussaulx E., Dutrillaux B., Zweibaum A.
Adaptation to 5-fluorouracil of the heterogeneous human colon tumor cell line HT-29 results in the selection of cells committed to differentiation.
Int. J. Cancer 49:721-730(1991)

PubMed=2041050; DOI=10.1093/jnci/83.11.757
Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K.D., Vistica D.T., Hose C.D., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R.
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991)

PubMed=1389533; DOI=10.1016/0959-8049(92)90031-V
Lahm H., Petral-Malec D., Yilmaz-Ceyhan A., Fischer J.R., Lorenzoni M., Givel J.-C., Odartchenko N.
Growth stimulation of a human colorectal carcinoma cell line by interleukin-1 and -6 and antagonistic effects of transforming growth factor beta 1.
Eur. J. Cancer 28A:1894-1899(1992)

PubMed=1730571; DOI=10.1007/BF02631079
Goodwin T.J., Jessup J.M., Wolf D.A.
Morphologic differentiation of colon carcinoma cell lines HT-29 and HT-29KM in rotating-wall vessels.
In Vitro Cell. Dev. Biol. Anim. 28:47-60(1992)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192
Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G., Bodmer W.F.
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163
Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P., Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H., Harris C.C.
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

PubMed=7651727
Kastrinakis W.V., Ramchurren N., Rieger K.M., Hess D.T., Loda M., Steele G., Summerhayes I.C.
Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.
Oncogene 11:647-652(1995)

PubMed=8895552; DOI=10.1002/(SICI)1097-0215(19960927)68:1<126::AID-IJC22>3.0.CO;2-8
Suardet L., Li C., Little J.B.
Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line.
Int. J. Cancer 68:126-131(1996)

PubMed=9000147
Cottu P.-H., Muzeau F., Estreicher A., Flejou J.-F., Iggo R.D., Thomas G., Hamelin R.
Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines.
Oncogene 13:2727-2730(1996)

PubMed=9000572
Hoang J.-M., Cottu P.-H., Thuille B., Salmon R.J., Thomas G., Hamelin R.
BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.
Cancer Res. 57:300-303(1997)

PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362
Ilyas M., Tomlinson I.P.M., Rowan A.J., Pignatelli M., Bodmer W.F.
Beta-catenin mutations in cell lines established from human colorectal cancers.
Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

PubMed=10612807; DOI=10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P; PMCID=PMC4721570
Ghadimi B.M., Sackett D.L., Difilippantonio M.J., Schrock E., Neumann T., Jauho A., Auer G., Ried T.
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations.
Genes Chromosomes Cancer 27:183-190(2000)

PubMed=10700174; DOI=10.1038/73432
Ross D.T., Scherf U., Eisen M.B., Perou C.M., Rees C., Spellman P.T., Iyer V.R., Jeffrey S.S., van de Rijn M., Waltham M.C., Pergamenschikov A., Lee J.C.F., Lashkari D., Shalon D., Myers T.G., Weinstein J.N., Botstein D., Brown P.O.
Systematic variation in gene expression patterns in human cancer cell lines.
Nat. Genet. 24:227-235(2000)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243
Rowan A.J., Lamlum H., Ilyas M., Wheeler J.M.D., Straub J., Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=11226274; DOI=10.1073/pnas.041603298; PMCID=PMC30173
Abdel-Rahman W.M., Katsura K., Rens W., Gorman P.A., Sheer D., Bicknell D.C., Bodmer W.F., Arends M.J., Wyllie A.H., Edwards P.A.W.
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.
Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.-J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11526487; DOI=10.1038/sj.onc.1204611
Gayet J., Zhou X.-P., Duval A., Rolland S., Hoang J.-M., Cottu P.-H., Hamelin R.
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.
Oncogene 20:5025-5032(2001)

PubMed=11668190; DOI=10.1177/002215540104901105
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=11687795; DOI=10.1038/ng754
Snijders A.M., Nowak N.J., Segraves R., Blackwood S., Brown N., Conroy J., Hamilton G., Hindle A.K., Huey B., Kimura K., Law S., Myambo K., Palmer J., Ylstra B., Yue J.P., Gray J.W., Jain A.N., Pinkel D., Albertson D.G.
Assembly of microarrays for genome-wide measurement of DNA copy number.
Nat. Genet. 29:263-264(2001)

PubMed=11921276; DOI=10.1002/gcc.10003
Kawai K., Viars C., Arden K.C., Tarin D., Urquidi V., Goodison S.
Comprehensive karyotyping of the HT-29 colon adenocarcinoma cell line.
Genes Chromosomes Cancer 34:1-8(2002)

PubMed=12068308; DOI=10.1038/nature00766
Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742
Adams S., Robbins F.-M., Chen D., Wagage D., Holbeck S.L., Morse H.C. 3rd, Stroncek D., Marincola F.M.
HLA class I and II genotype of the NCI-60 cell lines.
J. Transl. Med. 3:11.1-11.8(2005)

PubMed=15900046; DOI=10.1093/jnci/dji133
Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y., Yamazaki K., Hamada J.-i., Tada M., Moriuchi T., Ishikawa Y., Kato Y., Tomoda H., Yamori T., Tsuruo T.
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
J. Natl. Cancer Inst. 97:765-777(2005)

PubMed=16083285; DOI=10.1021/pr050048h
Kim J.-E., Tannenbaum S.R., White F.M.
Global phosphoproteome of HT-29 human colon adenocarcinoma cells.
J. Proteome Res. 4:1339-1346(2005)

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PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494
Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.
Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile.
Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=36648961; DOI=10.3390/proteomes11010003; PMCID=PMC9844407
Heck K.A., Lindholm H.T., Niederdorfer B., Tsirvouli E., Kuiper M., Flobak A., Laegreid A., Thommesen L.
Characterisation of colorectal cancer cell lines through proteomic profiling of their extracellular vesicles.
Proteomes 11:3.1-3.20(2023)

Cross-references
Cell line collections (Providers) AddexBio; C0009004/48
ATCC; HTB-38
BCRJ; 0111
CCLV; CCLV-RIE 0960
CCTCC; GDC0149
CLS; 300215
DSMZ; ACC-299
ECACC; 91072201
IBRC; C10097
ICLC; HTL99026
IZSLER; BS TCL 132
KCB; KCB 200508YJ
KCLB; 30038
NCBI_Iran; C466
NCI-DTP; HT-29
Ubigene; YC-C008
Cell line databases/resources CLO; CLO_0004283
MCCL; MCC:0000213
CLDB; cl1747
CLDB; cl1748
CLDB; cl1749
CLDB; cl1751
CLDB; cl1752
CLDB; cl1753
CLDB; cl1754
CLDB; cl4978
CLDB; cl5205
cancercelllines; CVCL_0320
CCRID; 1101HUM-PUMC000109
CCRID; 3101HUMSCSP5032
CCRID; 3101HUMTCHu103
CCRID; 4201HUM-CCTCC00149
CCRID; 5301HUM-KCB05008YJ
Cell_Model_Passport; SIDM00136
ColonAtlas; HT29
Cosmic-CLP; 905939
DepMap; ACH-000552
DSMZCellDive; ACC-299
LINCS_LDP; LCL-1180
Lonza; 430
SKY/M-FISH/CGH; 1435
SKY/M-FISH/CGH; 2124
SKY/M-FISH/CGH; 2836
TOKU-E; 1968
Anatomy/cell type resources BTO; BTO_0000182
Biological sample resources BioSample; SAMN01821565
BioSample; SAMN03470953
BioSample; SAMN05292462
BioSample; SAMN10988348
ENCODE; ENCBS604AAA
ENCODE; ENCBS605AAA
ENCODE; ENCBS668UDT
ENCODE; ENCBS814TLB
ENCODE; ENCBS836FPI
ENCODE; ENCBS914HXH
CRISP screens repositories BioGRID_ORCS_Cell_line; 179
Chemistry resources ChEMBL-Cells; CHEMBL3307768
ChEMBL-Targets; CHEMBL384
GDSC; 905939
PharmacoDB; HT29_630_2019
PubChem_Cell_line; CVCL_0320
Encyclopedic resources Wikidata; Q28334700
Experimental variables resources EFO; EFO_0001193
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM811
GEO; GSM2112
GEO; GSM50190
GEO; GSM50254
GEO; GSM206503
GEO; GSM274780
GEO; GSM288491
GEO; GSM288497
GEO; GSM288499
GEO; GSM513815
GEO; GSM514295
GEO; GSM736967
GEO; GSM741261
GEO; GSM743445
GEO; GSM799333
GEO; GSM799396
GEO; GSM827150
GEO; GSM887141
GEO; GSM888212
GEO; GSM1006213
GEO; GSM1006214
GEO; GSM1006215
GEO; GSM1153403
GEO; GSM1178239
GEO; GSM1178240
GEO; GSM1178241
GEO; GSM1181252
GEO; GSM1181366
GEO; GSM1346844
GEO; GSM1374561
GEO; GSM1374562
GEO; GSM1374563
GEO; GSM1374564
GEO; GSM1448179
GEO; GSM1669913
GEO; GSM2124658
GEO; GSM2550003
Medical resources MeSH; D019073
Metabolomic databases MetaboLights; MTBLS227
MetaboLights; MTBLS1358
Polymorphism and mutation databases Cosmic; 685867
Cosmic; 711273
Cosmic; 720331
Cosmic; 738929
Cosmic; 755308
Cosmic; 875295
Cosmic; 875898
Cosmic; 876716
Cosmic; 887217
Cosmic; 889523
Cosmic; 897459
Cosmic; 902789
Cosmic; 905939
Cosmic; 913891
Cosmic; 934562
Cosmic; 948132
Cosmic; 974246
Cosmic; 983739
Cosmic; 995412
Cosmic; 1043817
Cosmic; 1045405
Cosmic; 1057765
Cosmic; 1067225
Cosmic; 1071887
Cosmic; 1092605
Cosmic; 1122326
Cosmic; 1132575
Cosmic; 1154652
Cosmic; 1175842
Cosmic; 1176613
Cosmic; 1184093
Cosmic; 1184326
Cosmic; 1223142
Cosmic; 1248331
Cosmic; 1295658
Cosmic; 1299294
Cosmic; 1305355
Cosmic; 1310947
Cosmic; 1312339
Cosmic; 1436019
Cosmic; 1466816
Cosmic; 1479609
Cosmic; 1481417
Cosmic; 1482521
Cosmic; 1524327
Cosmic; 1537489
Cosmic; 1571769
Cosmic; 1609503
Cosmic; 1676733
Cosmic; 1708406
Cosmic; 1803945
Cosmic; 1888955
Cosmic; 1889160
Cosmic; 1933016
Cosmic; 1945866
Cosmic; 1995448
Cosmic; 1998447
Cosmic; 2052596
Cosmic; 2036654
Cosmic; 2145575
Cosmic; 2156939
Cosmic; 2301545
Cosmic; 2301988
Cosmic; 2389572
Cosmic; 2433757
Cosmic; 2550354
Cosmic; 2646771
Cosmic; 2664047
Cosmic; 2667882
Cosmic; 2668251
Cosmic; 2727481
Cosmic; 2760077
Cosmic; 2787549
Cosmic; 2800591
Cosmic; 2811052
IARC_TP53; 23
LiGeA; CCLE_686
Progenetix; CVCL_0320
Proteomic databases PRIDE; PRD000369
PRIDE; PRD000414
PRIDE; PXD001271
PRIDE; PXD001550
PRIDE; PXD003623
PRIDE; PXD005235
PRIDE; PXD005354
PRIDE; PXD005355
PRIDE; PXD005942
PRIDE; PXD005946
PRIDE; PXD030304
PRIDE; PXD037651
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number50