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Cellosaurus MV-522 (CVCL_7204)

[Text version]
Cell line name MV-522
Synonyms MV522; Metastatic Variant-522; Metastatic Variant 522; Line 522
Accession CVCL_7204
Resource Identification Initiative To cite this cell line use: MV-522 (RRID:CVCL_7204)
Comments Problematic cell line: Contaminated. Shown to be a HT-29 derivative. Originally thought to originate from a 53 year old male patient with a lung squamous cell carcinoma. It was thought to be a metastatic derivative of UCLA-P3 (Cellosaurus=CVCL_N513).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00409.
Population: Caucasian.
Misspelling: MU522; Cosmic=1945858.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Children:
CVCL_0E37 (MV522/MDR1)CVCL_0E38 (MV522/MRP)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO11,12
D5S81811,12
D7S82010
D13S31711,12
D16S53911,12
TH016,9
TPOX8,9
vWA17,19

Run an STR similarity search on this cell line
Web pages https://www.atcc.org/en/support/technical-support/faqs/mv522-atcc-crl-2519
https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=3596831; DOI=10.1002/ijc.2910400109
Varki N.M., Roome L., Sparkes R.S., Miller J.E.
Microscopic metastasis of a human lung carcinoma cell line in athymic nude mice: isolation of a metastatic variant.
Int. J. Cancer 40:46-52(1987)

Cross-references
Cell line collections (Providers) ATCC; CRL-2519 - Discontinued
Anatomy/cell type resources BTO; BTO:0004952
Biological sample resources BioSample; SAMN03151795
Encyclopedic resources Wikidata; Q54907106
Polymorphism and mutation databases Cosmic; 1173992
Cosmic; 1945858
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number28