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Cellosaurus HT-29 BR100 (CVCL_DH88)

[Text version]
Cell line name HT-29 BR100
Synonyms HT29 BR100; BR100
Accession CVCL_DH88
Resource Identification Initiative To cite this cell line use: HT-29 BR100 (RRID:CVCL_DH88)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:52717; Bortezomib (Velcade).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=22216088; DOI=10.1371/journal.pone.0027996; PMCID=PMC3245226
Suzuki E., Demo S., Deu E., Keats J.J., Arastu-Kapur S., Bergsagel P.L., Bennett M.K., Kirk C.J.
Molecular mechanisms of bortezomib resistant adenocarcinoma cells.
PLoS ONE 6:E27996-E27996(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DH88
Encyclopedic resources Wikidata; Q54896509
Gene expression databases GEO; GSM736968
Polymorphism and mutation databases Progenetix; CVCL_DH88
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number17