Cell line name |
HT29-16E |
Synonyms |
HT29 16E; HT-29 16E; HT29-Cl.16E; HT29-cl16E; HT29 clone 16E; Cl.16E |
Accession |
CVCL_C763 |
Resource Identification Initiative |
To cite this cell line use: HT29-16E (RRID:CVCL_C763) |
Comments |
Population: Caucasian. Doubling time: 43.37 hours (PubMed=25944804). Misspelling: C1.16E; Note=Occasionally. Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0320 (HT-29) |
Sex of cell |
Female |
Age at sampling |
44Y |
Category |
Cancer cell line |
Publications | PubMed=6744312 Augeron C., Laboisse C.L. Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate. Cancer Res. 44:3961-3969(1984) PubMed=8801204; DOI=10.1136/gut.38.2.240; PMCID=PMC1383030 Jarry A., Vallette G., Branka J.-E., Laboisse C.L. Direct secretory effect of interleukin-1 via type I receptors in human colonic mucous epithelial cells (HT29-Cl.16E). Gut 38:240-242(1996) PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457 Bazzocco S., Dopeso H., Carton-Garcia F., Macaya I., Andretta E., Chionh F., Rodrigues P., Garrido M., Alazzouzi H., Nieto R., Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D. Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment. Clin. Cancer Res. 21:3695-3704(2015) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_C763
|
Encyclopedic resources |
Wikidata; Q54896586
|
Entry history |
Entry creation | 22-Oct-2012 |
Last entry update | 05-Oct-2023 |
Version number | 22 |
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