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Cellosaurus HT29-16E (CVCL_C763)

[Text version]
Cell line name HT29-16E
Synonyms HT29 16E; HT-29 16E; HT29-Cl.16E; HT29-cl16E; HT29 clone 16E; Cl.16E
Accession CVCL_C763
Resource Identification Initiative To cite this cell line use: HT29-16E (RRID:CVCL_C763)
Comments Population: Caucasian.
Doubling time: 43.37 hours (PubMed=25944804).
Misspelling: C1.16E; Note=Occasionally.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=6744312
Augeron C., Laboisse C.L.
Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate.
Cancer Res. 44:3961-3969(1984)

PubMed=8801204; DOI=10.1136/gut.38.2.240
Jarry A., Vallette G., Branka J.-E., Laboisse C.L.
Direct secretory effect of interleukin-1 via type I receptors in human colonic mucous epithelial cells (HT29-Cl.16E).
Gut 38:240-242(1996)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Bazzocco S., Dopeso H., Carton-Garcia F., Macaya I., Andretta E., Chionh F., Rodrigues P., Garrido M., Alazzouzi H., Nieto R., Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C763
Encyclopedic resources Wikidata; Q54896586
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number22