| Cell line name |
HT-29 Y1-7 |
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| Synonyms |
Y1-7 |
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| Accession |
CVCL_C1KQ |
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| Resource Identification Initiative |
To cite this cell line use: HT-29 Y1-7 (RRID:CVCL_C1KQ) |
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| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=RGD; 3198; Npy1r.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0320 (HT-29) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8886416; DOI=10.1111/j.1476-5381.1996.tb15989.x; PMCID=PMC1915860
Holliday N.D., Cox H.M.
The functional investigation of a human adenocarcinoma cell line, stably transfected with the neuropeptide Y Y1 receptor.
Br. J. Pharmacol. 119:321-329(1996) CLPUB00715
Holliday N.D.
Functional expression of native and mutant Y1 receptors in stably transfected adenocarcinoma cell lines.
Thesis PhD (1998); University College London; London; United Kingdom PubMed=10737675; DOI=10.1139/y99-123
Holliday N.D., Pollock E.L., Tough I.R., Cox H.M.
PYY preference is a common characteristic of neuropeptide Y receptors expressed in human, rat, and mouse gastrointestinal epithelia.
Can. J. Physiol. Pharmacol. 78:126-133(2000) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_C1KQ
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| Encyclopedic resources |
Wikidata; Q114311669
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| Entry history |
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| Entry creation | 22-Sep-2022 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 6 |
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