Cell line name |
HT-29/cDDP |
Synonyms |
HT/DDP |
Accession |
CVCL_Y177 |
Resource Identification Initiative |
To cite this cell line use: HT-29/cDDP (RRID:CVCL_Y177) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP). Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0320 (HT-29) |
Sex of cell |
Female |
Age at sampling |
44Y |
Category |
Cancer cell line |
Publications | PubMed=9816187 Yamada M., Tomida A., Yoshikawa H., Taketani Y., Tsuruo T. Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines. Clin. Cancer Res. 2:427-432(1996) PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2 Yasui K., Mihara S., Zhao C., Okamoto H., Saito-Ohara F., Tomida A., Funato T., Yokomizo A., Naito S., Imoto I., Tsuruo T., Inazawa J. Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res. 64:1403-1410(2004) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_Y177
CGH-DB; 9104-4
|
Encyclopedic resources |
Wikidata; Q54896527
|
Entry history |
Entry creation | 07-Nov-2014 |
Last entry update | 19-Dec-2024 |
Version number | 19 |
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