| Cell line name |
2474/90 |
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| Synonyms |
St 2474; St2474 |
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| Accession |
CVCL_9556 |
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| Resource Identification Initiative |
To cite this cell line use: 2474/90 (RRID:CVCL_9556) |
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| Comments |
Problematic cell line: Contaminated. Shown to be a HT-29 derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a 60 year old male patient with a gastric carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00107.
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0320 (HT-29) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Web pages |
https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx |
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| Publications | PubMed=8100658; DOI=10.1007/BF02899281
Vollmers H.P., Stulle K., Dammrich J., Pfaff M., Papadopoulos T., Betz C., Saal K., Muller-Hermelink H.-K.
Characterization of four new gastric cancer cell lines.
Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol. 63:335-343(1993) PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G.
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999) PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_9556
|
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| Biological sample resources |
BioSample; SAMN03151783
|
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| Encyclopedic resources |
Wikidata; Q54583541
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| Entry history |
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| Entry creation | 06-Jun-2012 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 28 |
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