| Cell line name |
HT-29-D4 |
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| Synonyms |
HT 29-D4; HT29-D4 |
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| Accession |
CVCL_8118 |
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| Resource Identification Initiative |
To cite this cell line use: HT-29-D4 (RRID:CVCL_8118) |
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| Comments |
Population: Caucasian.
Characteristics: Can be induced to differentiate into enterocyte-like cells by replacing glucose with galactose in the culture medium (PubMed=3543033).
Doubling time: 48 hours (Note=With glucose), 60 hours (Note=With galactose) (PubMed=3543033).
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0320 (HT-29) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=3543033; DOI=10.1242/jcs.83.1.235
Fantini J., Abadie B., Tirard A., Remy L., Ripert J.-P., El-Battari A., Marvaldi J.
Spontaneous and induced dome formation by two clonal cell populations derived from a human adenocarcinoma cell line, HT29.
J. Cell Sci. 83:235-249(1986) PubMed=2736330; DOI=10.1111/j.1768-322X.1989.tb00785.x
Fantini J., Verrier B., Marvaldi J., Mauchamp J.
In vitro differentiated HT 29-D4 clonal cell line generates leakproof and electrically active monolayers when cultured in porous-bottom culture dishes.
Biol. Cell 65:163-169(1989) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_8118
Lonza; 371
|
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| Encyclopedic resources |
Wikidata; Q54896512
|
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 23 |
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