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Cellosaurus HT29-Lucia AhR (CVCL_A8BX)

[Text version]
Cell line name HT29-Lucia AhR
Accession CVCL_A8BX
Resource Identification Initiative To cite this cell line use: HT29-Lucia AhR (RRID:CVCL_A8BX)
Comments Population: Caucasian.
Characteristics: Used for the study of aryl hydrocarbon receptor (AhR) genomic signaling induction (InvivoGen).
Characteristics: The Lucia luciferase reporter gene is under the control of a minimal promoter coupled with the human CYP1A1 gene entire regulatory sequence which contains 6 dioxin responsive elements (DRE).
Genetic integration: Method=Transfection/transduction; Gene=Lucia luciferase (Note=Synthetic gene designed on natural secreted luciferase genes from marine copepods).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Web pages https://www.invivogen.com/ht29-lucia-ahr
Cross-references
Cell line databases/resources cancercelllines; CVCL_A8BX
Encyclopedic resources Wikidata; Q107115371
Entry history
Entry creation20-May-2021
Last entry update10-Sep-2024
Version number9