| Cell line name |
HT-29/5-FU |
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| Accession |
CVCL_0I27 |
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| Resource Identification Initiative |
To cite this cell line use: HT-29/5-FU (RRID:CVCL_0I27) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_46345; 5-fluorouracil (5-FU).
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0320 (HT-29) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=25744837; DOI=10.13423/j.cnki.cjcmi.007241
Qiu T.-T., Xiang X.-J., Lei W., Hao C., Zhang L., Feng M., Yu F., Li J.-H., Xiong J.-P.
Establishment and biological characterization of 5-fluorouracil-resistant human colon cancer HT-29/5-FU cell line.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31:328-332(2015) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_0I27
|
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| Encyclopedic resources |
Wikidata; Q54896521
|
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| Entry history |
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| Entry creation | 10-Apr-2015 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 19 |
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