| Cell line name |
HT-29 HD8 |
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| Synonyms |
HD8 |
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| Accession |
CVCL_H255 |
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| Resource Identification Initiative |
To cite this cell line use: HT-29 HD8 (RRID:CVCL_H255) |
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| Comments |
Population: Caucasian.
Characteristics: Clone of HT-29 established after treatment with hexamethylene bisacetamide (HMBA).
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0320 (HT-29) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=2288877
Hafez M.M., Infante D., Winawer S.J., Friedman E.
Transforming growth factor beta 1 acts as an autocrine-negative growth regulator in colon enterocytic differentiation but not in goblet cell maturation.
Cell Growth Differ. 1:617-626(1990) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_H255
|
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| Encyclopedic resources |
Wikidata; Q54882128
|
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| Entry history |
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| Entry creation | 11-Feb-2013 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 21 |
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