| Cell line name |
HT-29R13 |
|---|
| Accession |
CVCL_4V27 |
|---|
| Resource Identification Initiative |
To cite this cell line use: HT-29R13 (RRID:CVCL_4V27) |
|---|
| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27504; Mitomycin C (MMC; MitC).
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
|---|
| Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
|---|
| Disease |
Colon adenocarcinoma (NCIt: C4349) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0320 (HT-29) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
44Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=7903534; DOI=10.1016/0006-2952(93)90642-A
Perry R.R., Kang Y., Greaves B.R.
Biochemical characterization of a mitomycin C resistant colon cancer cell line variant.
Biochem. Pharmacol. 46:1999-2005(1993) PubMed=8324877; DOI=10.1007/BF00686181
Perry R.R., Greaves B.R., Kang Y.
Development and initial characterization of a mitomycin C-resistant colon cancer cell line variant.
Cancer Chemother. Pharmacol. 32:326-328(1993) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_4V27
|
|---|
| Encyclopedic resources |
Wikidata; Q54896534
|
|---|
| Entry history |
|---|
| Entry creation | 14-Dec-2015 |
|---|
| Last entry update | 05-Oct-2023 |
|---|
| Version number | 17 |
|---|
