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Cellosaurus HT29-18 (CVCL_5940)

[Text version]
Cell line name HT29-18
Accession CVCL_5940
Resource Identification Initiative To cite this cell line use: HT29-18 (RRID:CVCL_5940)
Comments Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Children:
CVCL_5941 (HT29-18-C1)CVCL_5942 (HT29-18-N2)CVCL_C766 (HT29-18A)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=3611191; DOI=10.1083/jcb.105.1.345
Huet C., Sahuquillo-Merino C., Coudrier E., Louvard D.
Absorptive and mucus-secreting subclones isolated from a multipotent intestinal cell line (HT-29) provide new models for cell polarity and terminal differentiation.
J. Cell Biol. 105:345-357(1987)

PubMed=8470895; DOI=10.1006/abbi.1993.1197
Oliva M.M., Wu T.-C., Yang V.W.
Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18.
Arch. Biochem. Biophys. 302:183-192(1993)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5940
Encyclopedic resources Wikidata; Q54896587
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22