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Cellosaurus HT-29/SN-38 (CVCL_WV61)

[Text version]
Cell line name HT-29/SN-38
Accession CVCL_WV61
Resource Identification Initiative To cite this cell line use: HT-29/SN-38 (RRID:CVCL_WV61)
Comments Population: Caucasian.
Doubling time: 30 hours (PubMed=23546019).
Selected for resistance to: ChEBI; CHEBI_8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=23546019; DOI=10.3892/ijo.2013.1868
Petitprez A., Poindessous V., Ouaret D., Regairaz M., Bastian G., Guerin E., Escargueil A.E., Larsen A.K.
Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status.
Int. J. Oncol. 42:1644-1653(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WV61
Encyclopedic resources Wikidata; Q94304661
Entry history
Entry creation05-Jul-2019
Last entry update19-Dec-2024
Version number11