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Cellosaurus HTOXAR3 (CVCL_8476)

[Text version]
Cell line name HTOXAR3
Synonyms HTOXAR-3
Accession CVCL_8476
Resource Identification Initiative To cite this cell line use: HTOXAR3 (RRID:CVCL_8476)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:31941; Oxaliplatin (Elotaxin; L-OHP).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=16773204; DOI=10.3892/ijo.29.1.225
Plasencia C., Martinez-Balibrea E., Martinez-Cardus A., Quinn D.I., Abad A., Neamati N.
Expression analysis of genes involved in oxaliplatin response and development of oxaliplatin-resistant HT29 colon cancer cells.
Int. J. Oncol. 29:225-235(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8476
Anatomy/cell type resources BTO; BTO:0005026
Encyclopedic resources Wikidata; Q54896674
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23