| Cell line name |
KM20L2 |
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| Synonyms |
KM-20L2; KM 20L2; KM 2012 |
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| Accession |
CVCL_D889 |
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| Resource Identification Initiative |
To cite this cell line use: KM20L2 (RRID:CVCL_D889) |
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| Comments |
Problematic cell line: Contaminated. Shown to be a HT-29 derivative (PubMed=15703300; resulting in a decision not to include the cell line in the NCI60 panel).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00514.
Population: Caucasian.
Misspelling: KM202L; Note=Occasionally.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0320 (HT-29) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Web pages |
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; NCI DTP; NCI-60 additional lines; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm |
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| Publications | PubMed=3349467
Kiyoshi Morikawa, Shirley M. Walker, John Milburn Jessup, Isaiah Joshua Fidler;
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.
Cancer Res. 48:1943-1948(1988) PubMed=2041050; DOI=10.1093/jnci/83.11.757
Anne Monks, Dominic A. Scudiero, Philip Skehan, Robert H. Shoemaker, Kenneth D. Paull, David T. Vistica, Curtis D. Hose, John Langley, Paul Cronise, Anne Vaigro-Wolff, Marcia Gray-Goodrich ...Show all 14 authors... , Hugh Campbell, Joseph G. Mayo, Michael R. Boyd; Show fewer authors
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991) PubMed=15703300; DOI=10.1073/pnas.0405578102; PMCID=PMC549443
Anna V. Roschke, Samir Lababidi, Giovanni Tonon, Kristen Stover Gehlhaus, Kimberly J. Bussey, John N. Weinstein, Ilan R. Kirsch;
Karyotypic 'state' as a potential determinant for anticancer drug discovery.
Proc. Natl. Acad. Sci. U.S.A. 102:2964-2969(2005) |
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| Cross-references |
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| Cell line collections (Providers) |
NCI-DTP; KM 20L2
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| Cell line databases/resources |
cancercelllines; CVCL_D889
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| Anatomy/cell type resources |
BTO; BTO_0005911
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| Biological sample resources |
BioSample; SAMN06481115
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| Chemistry resources |
ChEMBL-Cells; CHEMBL3307782
ChEMBL-Targets; CHEMBL614791
PubChem_Cell_line; CVCL_D889
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| Encyclopedic resources |
Wikidata; Q54900067
|
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| Polymorphism and mutation databases |
IARC_TP53; 28215
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| Entry history |
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| Entry creation | 22-Oct-2012 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 32 |
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