Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines
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The following breast cancer and normal breast cell lines have been analysed by SKY. A few have also been analyzed by CGH. The linked pages show representative SKY karyotypes and some additional comment.
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SK-BR-3 [1] |
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SK-BR-7 [1] |
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CAL51 [1] |
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MCF7 [1] |
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MDA-MB-134 [1] |
SUM-159 [1,6] |
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MDA-MB-157 [1] |
T-47D [1] |
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MDA-MB-175 [1] |
VP229 [1] |
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MDA-MB-361 [1] |
VP267 [1] |
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ZR-75-1 [1] |
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ZR-75-30 [1] |
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Normal
Breast: |
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MT-1 (HeLa contaminated) [1,2] |
HB4a [1,3] |
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HCC1937 [4, 5] |
PMC42 [1] |
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References to the SKY data and comments.
Unreferenced lines are unpublished work by Susanna Cooke, Katherine Blood, Mira Grigorova and Joanne Staines (née Davidson)
[1] Davidson et al. Br. J. Cancer 2000;83:1309-1317. PMID: 11044355
[2] These lines are HeLa contaminants, see MacLeod RAF, Dirks WG, Matsuo Y, Kaufmann M, Milch H, Drexler HG. Int. J. Cancer (1999);83:555-563. PMID: 10508494
[3] Immortalized normal lumenal breast epithelium; Stamps AC, Davies SC, Burman J, O'Hare MJ. Analysis of proviral integration in human mammary epithelial cell lines immortalized by retroviral infection with a temperature-sensitive SV40 T-antigen construct. Int. J. Cancer. (1994);57(6):865-874. PMID: 8206680
[4] Grigorova M, Staines JM, Ozdag H, Caldas C, Edwards PAW. Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. Cytogenet. Genome Res. 2004;104(1-4):333-340. PMID: 15162061
[5] BRCA1 mutant
[6] The SUM lines are described at SLKBase. CGH of these is included in Forozan F, Mahlamaki EH, Monni O, Chen Y, Veldman R, Jiang Y, Gooden GC, Ethier SP, Kallioniemi A, Kallioniemi O-P. Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray. Cancer Res. 2000;60:4519-4525. PMID: 10969801
[7] Now known to be from a melanoma, see linked page