Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > HCC1954

HCC1954   [Cellosaurus entry CVCL_1259]

Breast Cancer Cell Line

Description

A tetraploid cell line from mammary gland, breast, duct, ductal carcinoma, extremely rearranged with 35 structural chromosome rearrangements involving all chromosomes except 11 and 16, with hsrs involving chromosomes 8, 21 and 22. Held by ATCC.

   
Notable Features

   
Representative SKY Karyotype
   
   

90(89-94), XX, der(X?)t(X;38), der(X?)t(X; ?;2;5?;1)??, 1x3, der(1)t(1;5), der(1)t(1;10), der(1)t(1;?3?;5;?X), 2x1, del(2), der(2;8;17), der(2)t(2;8;4), 3x2, der(3)del(3), 4x2, der(4)t(3;4;13/18;1)?, del(4), 5x3, i(5p)?, del(5)t(5;?)?, 6x4, der(6)del(6)(q10-qter), 7x5, 8x1, der(8)t(5;8), del(8)(p10-pter), der(8)t(13;8;9)?, 9x2, der(9)t(20, 9hsr,X/5/22?)x2, der(9)t(9q;8p), 10x3, der(10?)t(7p;10p)a, 11x3, 12x2, der(12)del(12)(p10-pter), 13x2, der(13;17)(q10;q10), i(14q)t(14;1;14) b, der(14)t(14q;22hsr;5q), 15x3, der(15;19)(q10;q10), 16x4, 17x4, i(17q)/isoder(17;10)??, der(17)t(17;10/22?), 18x3, der(18)t(9;18), 19x1, der(19)t(18;19), der(19)t(19;8;17), der(19)t(19;8;3), der(19)t(2/X;19), 20x2, der(20)t(20;19;5), der(16;21)(q10;q10); der(14;21)(q10;q10), 22x2, der(22)t(5;22), der(22)t(22;hsr8?;hsr21?)

a  in less than 50% of the cells
b  i(14q) has a strip of chr 1 on one arm and is probably more complex

   
 


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Breast Cancer Cell Lines