Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > SUM-159

SUM-159   [Cellosaurus entry CVCL_5423]

Breast Cancer Cell Line


Breast carcinoma cell line. Obtained from the originators. One of the SUM series of lines derived in Ethier's laboratory*.

Notable Features

A hyperdiploid cell line with modal chromosome number of 47 and 9 structural translocations, one reciprocal translocation t(X;9) and one possible reciprocal  translocation t(7;17) – the der(7) is observed in only two cells (the breakpoint is very terminal and could be misclassified); the der(17) is replaced by another der(17) t(7;17;4;11;3) in three cells which is a different clone and in these cells chr 2 has a translocated  chr 17segment, which is not present in the first clone. The der(14?)t(14;13;8), is the same der(13)t(8;13), translocated as Rb fusion to chr 14. Gain of 5(q12-13- q ter).

Representative SKY Karyotype

47(46-59). 1x2, 2x2, 3x2, 4x2, 5x2, del(5)(q11.2), 6x2, 7x2, 8x2, 9x1, der(9)t(X;9), 10x2, 11x2, 12x2, 13x1, der(13)t(8;13), der(?)t(14;13;8), 14x1, 15x2, 16x2, 17x1, der(17)t(7;17)(p22;?), 18x2, 19x2, 20x2, 21x2, 22x2, Xx1, der(X)t(X;9) cp[10]

Additional Information  *Forozan F, Veldman R, Ammerman CA, Parsa NZ, Kallioniemi A, Kallioniemi OP, Ethier SP (1999) Molecular cytogenetic analysis of 11 new breast cancer cell lines. Br J Cancer 81: 1328-1334



Breast Cancer Cell Lines