Molecular
Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell
lines > BT20
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Breast Cancer Cell Line |
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Description |
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Notable Features |
Hyperdiploid, highly rearranged, with 30 structural rearrangements, some of them complex, with amplified region of chromosomes 6, 11, 20, most cells have double minutes (DMs), most involving chromosome1, some – chromosome 5. Losses involve chromosomes X, 1p, 8p, 10, 14, 17p; gains involve chromosomes 1q, 2, 7p, 20, 21. |
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Representative SKY Karyotype |
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48 (47-50) X, 1x1, der(1-14)(q10;q10), der(1)t(1q;5q;12), 2x1, der(2)t(2;8), der(2)t(X;2)dup(2), der(2)t(2;5)?, 3x1, der(3)del(3), der(3?)t(15;14;6?;3;9), 4x2, der(5)del(5)t(3;5), 6x1, der(6)t(6;7;6)(q23;?;q22-qter)dup(6)(q22-qter), 7x2, der(6-7)t(6;7p), i(7p), 8x1, der(8)t(16/5?;8q;5q), der(9?)t(der(9)t(X;9)?, der(9)t(9;10), der(9)t(5/16)dic(9-9), der(10)del(10)(q11-qter), der(10)t(X;10), der(10?)t(10;20)?, 11x1, der(11)t(5;11q)dup(11)(q14-qter), 12x1, der(12)t(12;2/X;12), 13x1, der(13)t(8;13q); der(14)del(14), 15x1, der(15)t(14;15), 16x1, der(16)t(3;16), 17x1, der(17)del(17)(p11-pter), 18x1, der(18)t(7;18), 19x1, der(19)dic(11;19; 11;1;11;13), 20x1, der(20)t(20;X;10;X;20)dup(20), 21x1, dic(21-21), 22x1, der(22)t(1;22), dmin |
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