Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > HCC1806

HCC1806   [Cellosaurus entry CVCL_1258]

Breast Cancer Cell Line


A hyper-diploid cell line from mammary gland; breast; primary acantholytic squamous cell carcinoma, cells are homozygous for deletions in the FHIT gene at 3p14.2, held at ATCC, included in Cancer Genome Project at the Sanger Institute.

Notable Features

A hyper-diploid, extremely rearranged with 39 structural chromosome abnormalities, with rearrangements involving every chromosome. No normal chromosomes 2, 3, 4, 6, 7, 10, 12, 14, 21. Many complex rearrangements, however two reciprocal translocations – t(4;6) and t(12;22); the der(12) of the t(12;22) present in less than 50% of cells.

Losses involve X, 5q, 14, 16p, 18; gains involve 10q, 19, 19.

Representative SKY Karyotype

51(49-53), X, -X, 1x1, der(1;5)(p10;q10), -2, der(2)t(2;5;2)dup(2), del(2)t(2;12), der(2?)t(2;14), der(3)del(3), der(3)t(3;22)(p12;?), der(3)t(3;20)(p12;?), der(3)t(3;19), der(4)t(4;6)(p15;p12)*, der(4)t(1;4)(q11;p15), 5x1, der(5;10)t(p10;p10), der(6)t(4;6)(p15;p12)*, der(6)t(1;6p), der(6)del(6)(q10-qter), -7, der(7?)t(2;7), der(7)t(8;7;17), 8x1, der(8)del(8)(p12-pter), 9x1, der(9)t(9;12)(p21; p12?), -10, der(10)t(6;10)(?;p11), i(10q), 11x1, der(11)t(3;11), -12, der(12)t(12;13)(p12;?), der(12)t(12;22)(q13-14;q13)*a, der(12)del(12)(q13-qter), 13x1, der(13)t(13;2;7), der(13)t(13;11;13), -14, der(14)t(6;14)(?;p11.2), 15x1, isodic(15)t(15;10), der(15)del(15), 16x1, der(16)t(16q11.1;3p11;11p11-pter), 17x1, i(17q)t(3;17)/i((17q)t(3/;17;15), 18x1, 19x1, der(19)t(8;19), der(19)t(18;19), der(19)t(22;19;22), der(19)t(7;19;10), der(19)del(19), 20x2, -21, der(21)t(3;21), 22x1, der(22)t(21;22), der(22)t(12;22)(q13;q13)*

* reciprocal translocation




Breast Cancer Cell Lines