T-47D

Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > T-47D

T-47D [Cellosaurus entry CVCL_0553]

Breast Carcinoma Cell Line

Description A highly rearranged, near triploid cell line, held at the ATCC and obtained from the ECACC.

Notable Features Translocations involve chromosomes 1, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 20 and X. Five markers have been duplicated. Deletions were detected on chromosomes 3, 10 (duplicated), 11 (duplicated), 12 and 18.

Representative SKY Karyotype

62(44-66).1x2, der(16)t(1;16), 2x2, 3x2, del(3)(p?), der(?)ins(3;5), 4x2, der(?)t(4;5), 5x2, 6x2, 7x2, der(7)t(7;15)x2, 8x2, der(8)t(8;14)x2, 9x2, der(9)t(9;17)x2, der(10)t(10;20), der(10)t(10;20), der(10)t(3;10)x2, del(10)x2, 11x2, del(11)(p?)x2, 12x1, der(12)t(12;16), der(12)t(12;13), del(12)(p?), 13x2, 14x2, 15x1, der(?)ins(15;9)x2, 16x2, 17x2, 18x2, del(18), 19x2, 20x2, 21x2, 22x2, Xx1, der(X)t(X;6) cp[10]

CGH results

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Breast Cell Lines

Description	A highly rearranged, near triploid cell line, held at the ATCC and obtained from the ECACC.

Notable Features	Translocations involve chromosomes 1, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 20 and X. Five markers have been duplicated. Deletions were detected on chromosomes 3, 10 (duplicated), 11 (duplicated), 12 and 18.

Representative SKY Karyotype


62(44-66).1x2, der(16)t(1;16), 2x2, 3x2, del(3)(p?), der(?)ins(3;5), 4x2, der(?)t(4;5), 5x2, 6x2, 7x2, der(7)t(7;15)x2, 8x2, der(8)t(8;14)x2, 9x2, der(9)t(9;17)x2, der(10)t(10;20), der(10)t(10;20), der(10)t(3;10)x2, del(10)x2, 11x2, del(11)(p?)x2, 12x1, der(12)t(12;16), der(12)t(12;13), del(12)(p?), 13x2, 14x2, 15x1, der(?)ins(15;9)x2, 16x2, 17x2, 18x2, del(18), 19x2, 20x2, 21x2, 22x2, Xx1, der(X)t(X;6) cp[10]

CGH results