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Cellosaurus SW480 (CVCL_0546)

[Text version]
Cell line name SW480
Synonyms SW-480; SW 480; SW480E
Accession CVCL_0546
Resource Identification Initiative To cite this cell line use: SW480 (RRID:CVCL_0546)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
From: Scott and White Clinic; Temple; USA.
Population: Caucasian.
Doubling time: 50 hours (Note=At 73th passage) (PubMed=1000501); 30.74 hours (PubMed=25944804); 24 hours (PubMed=25984343); 20-25 hours (CLS=300302); ~25-30 hours (DSMZ=ACC-313); ~38 hours (PBCF).
Microsatellite instability: Stable (MSS) (PubMed=9000147; PubMed=10674020; PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746).
Omics: Deep exome analysis.
Omics: Deep phosphoproteome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Hi-C chromosome conformation analysis.
Omics: miRNA expression profiling.
Omics: N-glycan profiling.
Omics: Nuclear proteome analysis.
Omics: O-glycan profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Misspelling: WE-480; Note=Occasionally.
Misspelling: WE480; Note=Occasionally.
Misspelling: SW80; Note=Occasionally.
Misspelling: SWH80; BTO=BTO:0006552.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,24:02
HLA-BB*07:02,15:18
HLA-CC*07:04,07:04
Class II
HLA-DQDQA1*03:02,03:02
DQB1*05:01,06:11
HLA-DRDRB1*13:27,15:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.55
East Asian, North1.14
East Asian, South0.1
South Asian0.15
European, North58.36
European, South39.69
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B0YQ (Abcam SW480 ACAT1 KO)CVCL_B0YR (Abcam SW480 ALDH2 KO)CVCL_E1GG (Abcam SW480 BACE2 KO)
CVCL_E1GH (Abcam SW480 BID KO)CVCL_B0YS (Abcam SW480 DDIT3 KO)CVCL_B0YT (Abcam SW480 ELAVL1 KO)
CVCL_B0YU (Abcam SW480 ITGA6 KO)CVCL_B0YV (Abcam SW480 LCN2 KO)CVCL_B0YW (Abcam SW480 SERPINA1 KO)
CVCL_E1GI (Abcam SW480 STXBP1 KO)CVCL_8092 (BIC-1)CVCL_Y097 (CC-M2)
CVCL_Y099 (CC-M3)CVCL_F654 (CC-ML3)CVCL_KS03 (CellSensor LEF/TCF-bla SW480)
CVCL_C8D6 (SW480 M13OE)CVCL_A9MF (SW480-EGFP)CVCL_C8Y1 (SW480-Luc)
CVCL_A4BX (SW480-Luc2)CVCL_A9MG (SW480-Luc2-tdT)CVCL_A9MH (SW480-mCherry)
CVCL_A9MI (SW480-tdT)CVCL_AU16 (SW480/5FUR)CVCL_AU17 (SW480/BEVA)
CVCL_4Y13 (SW480/CMV-Luc)CVCL_AT66 (SW480/nkR)CVCL_AT65 (SW480/nkS)
CVCL_AU18 (SW480/OXR)CVCL_C3GM (SW480_6244R)CVCL_AT67 (SW480E)
CVCL_AT68 (SW480R)CVCL_3799 (SW527)CVCL_F649 (SW598)
CVCL_F653 (SW608)CVCL_F650 (SW613)CVCL_F651 (SW732)
CVCL_F652 (SW733)CVCL_9475 (TMC-1)CVCL_E1CF (Ubigene SW480 FBXW7 KO)
CVCL_E1CG (Ubigene SW480 HUNK KO)
Originate from same individual CVCL_0547 ! SW620
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0009001/43; ATCC=CCL-228; CCRID; CLS=300302; DSMZ=ACC-313; ECACC=87092801; KCLB=10228; PubMed=11416159; PubMed=25877200; PubMed=25926053; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO13,14
D1S165613,14
D2S44110,15
D2S133817,24
D3S135815
D5S81813
D7S8208
D8S117913
D10S124813,14
D12S39117
D13S31712
D16S53913
D18S5113
D19S43313
D21S1130,30.2
D22S104516
FGA24
Penta D9,15
Penta E10
TH018
TPOX11
vWA16

Run an STR similarity search on this cell line
Web pages https://www.atcc.org/en/support/technical-support/faqs/atcc-ccl-228-growth-and-morphology
https://www.synapse.org/#!Synapse:syn31544587
https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/SW480.html
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-54.html
https://tcpaportal.org/mclp/
Publications

PubMed=1000501
Leibovitz A., Stinson J.C., McCombs W.B. 3rd, McCoy C.E., Mazur K.C., Mabry N.D.
Classification of human colorectal adenocarcinoma cell lines.
Cancer Res. 36:4562-4569(1976)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=924690; DOI=10.1002/ijc.2910200505
Kerbel R.S., Pross H.F., Leibovitz A.
Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.
Int. J. Cancer 20:673-679(1977)

PubMed=286328; DOI=10.1073/pnas.76.3.1438; PMCID=PMC383267
Herlyn M., Steplewski Z., Herlyn D., Koprowski H.
Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 76:1438-1442(1979)

PubMed=288927; DOI=10.1093/jnci/63.3.635
Leibovitz A., Wright W.C., Pathak S., Siciliano M.J., Daniels W.P., Fogh H., Fogh J.
Detection and analysis of a glucose 6-phosphate dehydrogenase phenotype B cell line contamination.
J. Natl. Cancer Inst. 63:635-645(1979)

PubMed=7459858
Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=7104989; DOI=10.1016/0165-4608(82)90076-0
Chen T.-R., Hay R.J., Macy M.L.
Karyotype consistency in human colorectal carcinoma cell lines established in vitro.
Cancer Genet. Cytogenet. 6:93-117(1982)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3349466
Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x; PMCID=PMC5918361
Takeshima E., Hamaguchi M., Watanabe T., Akiyama S., Kataoka M., Ohnishi Y., Xiao H.-Y., Nagai Y., Takagi H.
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
Jpn. J. Cancer Res. 82:1428-1435(1991)

PubMed=1389533; DOI=10.1016/0959-8049(92)90031-V
Lahm H., Petral-Malec D., Yilmaz-Ceyhan A., Fischer J.R., Lorenzoni M., Givel J.-C., Odartchenko N.
Growth stimulation of a human colorectal carcinoma cell line by interleukin-1 and -6 and antagonistic effects of transforming growth factor beta 1.
Eur. J. Cancer 28A:1894-1899(1992)

PubMed=8422623; DOI=10.1002/1097-0142(19930115)71:2<315::AID-CNCR2820710208>3.0.CO;2-B
Tibbetts L.M., Doremus C.M., Tzanakakis G.N., Vezeridis M.P.
Liver metastases with 10 human colon carcinoma cell lines in nude mice and association with carcinoembryonic antigen production.
Cancer 71:315-321(1993)

PubMed=7651727
Kastrinakis W.V., Ramchurren N., Rieger K.M., Hess D.T., Loda M., Steele G., Summerhayes I.C.
Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.
Oncogene 11:647-652(1995)

PubMed=7824277
Eshleman J.R., Lang E.Z., Bowerfind G.K., Parsons R., Vogelstein B., Willson J.K.V., Veigl M.L., Sedwick W.D., Markowitz S.D.
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.
Oncogene 10:33-37(1995)

PubMed=8895552; DOI=10.1002/(SICI)1097-0215(19960927)68:1<126::AID-IJC22>3.0.CO;2-8
Suardet L., Li C., Little J.B.
Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line.
Int. J. Cancer 68:126-131(1996)

PubMed=9000147
Cottu P.-H., Muzeau F., Estreicher A., Flejou J.-F., Iggo R.D., Thomas G., Hamelin R.
Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines.
Oncogene 13:2727-2730(1996)

PubMed=9000572
Hoang J.-M., Cottu P.-H., Thuille B., Salmon R.J., Thomas G., Hamelin R.
BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.
Cancer Res. 57:300-303(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362
Ilyas M., Tomlinson I.P.M., Rowan A.J., Pignatelli M., Bodmer W.F.
Beta-catenin mutations in cell lines established from human colorectal cancers.
Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

PubMed=9715273; DOI=10.1038/sj.onc.1201986
Eshleman J.R., Casey G., Kochera M.E., Sedwick W.D., Swinler S.E., Veigl M.L., Willson J.K.V., Schwartz S., Markowitz S.D.
Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53.
Oncogene 17:719-725(1998)

PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3
Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.
Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.
Eur. J. Cancer 35:1724-1729(1999)

PubMed=10612807; DOI=10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P; PMCID=PMC4721570
Ghadimi B.M., Sackett D.L., Difilippantonio M.J., Schrock E., Neumann T., Jauho A., Auer G., Ried T.
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations.
Genes Chromosomes Cancer 27:183-190(2000)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243
Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J., Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=10773689; DOI=10.1159/000015508
Melcher R., Steinlein C., Feichtinger W., Muller C.R., Menzel T., Luehrs H., Scheppach W., Schmid M.
Spectral karyotyping of the human colon cancer cell lines SW480 and SW620.
Cytogenet. Cell Genet. 88:145-152(2000)

PubMed=11113861; DOI=10.1002/1096-9896(2000)9999:9999<::AID-PATH775>3.0.CO;2-K
Hewitt R.E., McMarlin A., Kleiner D.E., Wersto R.P., Martin P., Tsokos M.G., Stamp G.W.H., Stetler-Stevenson W.G.
Validation of a model of colon cancer progression.
J. Pathol. 192:446-454(2000)

PubMed=11226274; DOI=10.1073/pnas.041603298; PMCID=PMC30173
Abdel-Rahman W.M., Katsura K., Rens W., Gorman P.A., Sheer D., Bicknell D.C., Bodmer W.F., Arends M.J., Wyllie A.H., Edwards P.A.W.
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.
Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.-J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11526487; DOI=10.1038/sj.onc.1204611
Gayet J., Zhou X.-P., Duval A., Rolland S., Hoang J.-M., Cottu P.-H., Hamelin R.
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.
Oncogene 20:5025-5032(2001)

PubMed=11668190; DOI=10.1177/002215540104901105
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731
Liu Y., Bodmer W.F.
Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=16854228; DOI=10.1186/1476-4598-5-29; PMCID=PMC1550420
Bandres Elizalde E.M., Cubedo E., Agirre X., Malumbres R., Zarate R., Ramirez N., Abajo A., Navarro A., Moreno I., Monzo M., Garcia-Foncillas J.
Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues.
Mol. Cancer 5:29.1-29.10(2006)

PubMed=19927377; DOI=10.1002/gcc.20730; PMCID=PMC2818350
Knutsen T., Padilla-Nash H.M., Wangsa D., Barenboim-Stapleton L., Camps J., McNeil N.E., Difilippantonio M.J., Ried T.
Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines.
Genes Chromosomes Cancer 49:204-223(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514
Janakiraman M., Vakiani E., Zeng Z.-S., Pratilas C.A., Taylor B.S., Chitale D., Halilovic E., Wilson M., Huberman K., Ricarte Filho J.C.M., Persaud Y., Levine D.A., Fagin J.A., Jhanwar S.C., Mariadason J.M., Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer Res. 70:5901-5911(2010)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=20831567; DOI=10.1111/j.1582-4934.2010.01170.x; PMCID=PMC3918049
Ma Y.-L., Zhang P., Wang F., Moyer M.P., Yang J.-J., Liu Z.-H., Peng J.-Y., Chen H.-Q., Zhou Y.-K., Liu W.-J., Qin H.-L.
Human embryonic stem cells and metastatic colorectal cancer cells shared the common endogenous human microRNA-26b.
J. Cell. Mol. Med. 15:1941-1954(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A., Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A., Orphanides G., French T., Wessels L.F.A.
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=23932154; DOI=10.1016/j.radonc.2013.06.032
Salendo J., Spitzner M., Kramer F., Zhang X., Jo P., Wolff H.A., Kitz J., Kaulfuss S., Beissbarth T., Dobbelstein M., Ghadimi M., Grade M., Gaedcke J.
Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.
Radiother. Oncol. 108:451-457(2013)

PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225
Ahmed D., Eide P.W., Eilertsen I.A., Danielsen S.A., Eknaes M., Hektoen M., Lind G.E., Lothe R.A.
Epigenetic and genetic features of 24 colon cancer cell lines.
Oncogenesis 2:e71.1-e71.8(2013)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=24840470; DOI=10.1016/j.jprot.2014.05.002
Chik J.H.L., Zhou J., Moh E.S.X., Christopherson R., Clarke S.J., Molloy M.P., Packer N.H.
Comprehensive glycomics comparison between colon cancer cell cultures and tumours: implications for biomarker studies.
J. Proteomics 108:146-162(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25841592; DOI=10.1016/j.jprot.2015.03.019
Piersma S.R., Knol J.C., de Reus I., Labots M., Sampadi B.K., Pham T.V., Ishihama Y., Verheul H.M.W., Jimenez C.R.
Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines.
J. Proteomics 127:247-258(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Bazzocco S., Dopeso H., Carton-Garcia F., Macaya I., Andretta E., Chionh F., Rodrigues P., Garrido M., Alazzouzi H., Nieto R., Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26537799; DOI=10.1074/mcp.M115.051235; PMCID=PMC4762531
Holst S., Deuss A.J.M., van Pelt G.W., van Vliet S.J., Garcia-Vallejo J.J., Koeleman C.A.M., Deelder A.M., Mesker W.E., Tollenaar R.A.E.M., Rombouts Y., Wuhrer M.
N-glycosylation profiling of colorectal cancer cell lines reveals association of fucosylation with differentiation and caudal type homebox 1 (CDX1)/villin mRNA expression.
Mol. Cell. Proteomics 15:124-140(2016)

PubMed=27987026; DOI=10.1007/s00216-016-0125-5; PMCID=PMC5303640
Schunter A.J., Yue X.-S., Hummon A.B.
Phosphoproteomics of colon cancer metastasis: comparative mass spectrometric analysis of the isogenic primary and metastatic cell lines SW480 and SW620.
Anal. Bioanal. Chem. 409:1749-1763(2017)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28683746; DOI=10.1186/s12943-017-0691-y; PMCID=PMC5498998
Berg K.C.G., Eide P.W., Eilertsen I.A., Johannessen B., Bruun J., Danielsen S.A., Bjornslett M., Meza-Zepeda L.A., Eknaes M., Lind G.E., Myklebost O., Skotheim R.I., Sveen A., Lothe R.A.
Multi-omics of 34 colorectal cancer cell lines -- a resource for biomedical studies.
Mol. Cancer 16:116.1-116.16(2017)

PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344
Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R.-S., Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S., Johnstone E., Domingo E., Kerr D.J., Jesinghaus M., Slotta-Huspenina J., Weichert W., Knapp S., Feller S.M., Kuster B.
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

PubMed=29131639; DOI=10.1021/acs.jproteome.7b00548
Torres S., Garcia-Palmero I., Marin-Vicente C., Bartolome R.A., Calvino E., Fernandez-Acenero M.J., Casal J.I.
Proteomic characterization of transcription and splicing factors associated with a metastatic phenotype in colorectal cancer.
J. Proteome Res. 17:252-264(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31059103; DOI=10.3892/or.2019.7146
Wang Y.-Y., Zhou L., Qing Q., Li Y.-F., Li L.-X., Dong X.-Y., Xiao B.
Gene expression profile of cancer stem-like cells in the SW480 colon adenocarcinoma cell line.
Oncol. Rep. 42:386-398(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. 3rd, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=32172478; DOI=10.1007/s12253-020-00805-3
Xu Y.-T., Zhang L., Wang Q.-L., Zheng M.-J.
Comparison of different colorectal cancer with liver metastases models using six colorectal cancer cell lines.
Pathol. Oncol. Res. 26:2177-2183(2020)

Cross-references
Cell line collections (Providers) Abcam; ab271146
AddexBio; C0009001/43
ATCC; CCL-228
BCRC; 60249
BCRJ; 0411
CCTCC; GDC0065
CCTCC; GDC0306
CLS; 300302
DSMZ; ACC-313
ECACC; 87092801
ICLC; HTL99017
KCB; KCB 200848YJ
KCLB; 10228
NCBI_Iran; C506
RCB; RCB1959 - Discontinued
TKG; TKG 0505 - Discontinued
Ubigene; YC-C057
Cell line databases/resources CLO; CLO_0009195
CLO; CLO_0009217
CLO; CLO_0009218
MCCL; MCC:0000447
CLDB; cl4440
CLDB; cl4441
CLDB; cl4966
cancercelllines; CVCL_0546
CCRID; 1101HUM-PUMC000166
CCRID; 3101HUMSCSP5033
CCRID; 3101HUMTCHu172
CCRID; 4201HUM-CCTCC00306
Cell_Model_Passport; SIDM00840
ColonAtlas; SW480
DepMap; ACH-000842
DSMZCellDive; ACC-313
FCS-free; 180-2-342-3-16-3
IGRhCellID; SW480
Lonza; 816
SKY/M-FISH/CGH; 2839
SKY/M-FISH/CGH; 3982
TOKU-E; 3233
Anatomy/cell type resources BTO; BTO:0000038
BTO; BTO:0006552
Biological sample resources BioSample; SAMN01821602
BioSample; SAMN03481110
BioSample; SAMN05292431
BioSample; SAMN07709984
BioSample; SAMN07709985
BioSample; SAMN07709986
BioSample; SAMN07709987
BioSample; SAMN07709988
BioSample; SAMN07709989
BioSample; SAMN07709990
BioSample; SAMN10987646
ENCODE; ENCBS211HGL
ENCODE; ENCBS421AQW
Chemistry resources ChEMBL-Cells; CHEMBL3307758
ChEMBL-Targets; CHEMBL612544
PharmacoDB; SW480_1539_2019
PubChem_Cell_line; CVCL_0546
Encyclopedic resources Wikidata; Q28472974
Experimental variables resources EFO; EFO_0002083
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM206552
GEO; GSM274771
GEO; GSM274772
GEO; GSM513930
GEO; GSM514312
GEO; GSM741258
GEO; GSM784022
GEO; GSM861349
GEO; GSM861350
GEO; GSM861351
GEO; GSM861352
GEO; GSM887674
GEO; GSM888766
GEO; GSM1006234
GEO; GSM1006235
GEO; GSM1346891
GEO; GSM1374928
GEO; GSM1374929
GEO; GSM1374930
GEO; GSM1448166
GEO; GSM1670508
GEO; GSM1862124
GEO; GSM1862125
GEO; GSM1862126
GEO; GSM2299788
GEO; GSM2550016
GEO; GSM3258549
GEO; GSM3399745
GEO; GSM3399746
GEO; GSM3591767
Metabolomic databases MetaboLights; MTBLS227
Polymorphism and mutation databases Cosmic; 709847
Cosmic; 711272
Cosmic; 716169
Cosmic; 720332
Cosmic; 875293
Cosmic; 876719
Cosmic; 887240
Cosmic; 889536
Cosmic; 902791
Cosmic; 905006
Cosmic; 913892
Cosmic; 948827
Cosmic; 983732
Cosmic; 985652
Cosmic; 990302
Cosmic; 995393
Cosmic; 1043829
Cosmic; 1057764
Cosmic; 1066212
Cosmic; 1071888
Cosmic; 1122332
Cosmic; 1132573
Cosmic; 1132693
Cosmic; 1154645
Cosmic; 1176589
Cosmic; 1184095
Cosmic; 1184328
Cosmic; 1187323
Cosmic; 1223149
Cosmic; 1310935
Cosmic; 1332007
Cosmic; 1374642
Cosmic; 1466822
Cosmic; 1479588
Cosmic; 1482524
Cosmic; 1486130
Cosmic; 1524329
Cosmic; 1552183
Cosmic; 1571768
Cosmic; 1609479
Cosmic; 1676750
Cosmic; 1708398
Cosmic; 1803951
Cosmic; 2036653
Cosmic; 2145577
Cosmic; 2156941
Cosmic; 2267318
Cosmic; 2301547
Cosmic; 2302018
Cosmic; 2433752
Cosmic; 2646770
Cosmic; 2651869
Cosmic; 2664054
Cosmic; 2668252
Cosmic; 2727482
Cosmic; 2760071
Cosmic; 2787551
Cosmic; 2800590
Cosmic; 2823492
IARC_TP53; 96
IARC_TP53; 23572
LiGeA; CCLE_461
Progenetix; CVCL_0546
Proteomic databases PRIDE; PXD000089
PRIDE; PXD000230
PRIDE; PXD001550
PRIDE; PXD002793
PRIDE; PXD003708
PRIDE; PXD005354
PRIDE; PXD005355
PRIDE; PXD006662
PRIDE; PXD019478
PRIDE; PXD019479
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number48