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Cellosaurus CC-M2 (CVCL_Y097)

[Text version]
Cell line name CC-M2
Accession CVCL_Y097
Resource Identification Initiative To cite this cell line use: CC-M2 (RRID:CVCL_Y097)
Comments Problematic cell line: Contaminated. Shown to be a SW480 (or SW620) derivative (BCRC=60449). Originally thought to originate from a 58 year old male patient with a sigmoid colorectal carcinoma.
Population: Caucasian.
Doubling time: 20.0 hours (Note=At 25th passage), 18.5 hours (Note=At 50th passage) (PubMed=1696674).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser227Phe (c.680C>T); Zygosity=Unspecified (PubMed=15144569).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0546 (SW480)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
Web pages http://www.bcrc.firdi.org.tw/attach/2019-05-28/a.pdf
Publications

PubMed=1696674; DOI=10.1002/jso.2930440414
Cheng J.-Y., Meng C.-L., Lin J.-C., Tzeng C.-C., Chin L.-T., Shen K.-L.
Characterization of four newly established human colorectal adenocarcinoma cell lines from Chinese patients.
J. Surg. Oncol. 44:260-267(1990)

PubMed=15144569; DOI=10.1089/107999004323034105
Juang S.-H., Wei S.-J., Hung Y.-M., Hsu C.-Y., Yang D.-M., Liu K.-J., Chen W.-S., Yang W.K.
IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.
J. Interferon Cytokine Res. 24:231-243(2004)

Cross-references
Cell line collections (Providers) BCRC; 60449 - Discontinued
Cell line databases/resources cancercelllines; CVCL_Y097
Encyclopedic resources Wikidata; Q54808712
Entry history
Entry creation07-Nov-2014
Last entry update30-Jan-2024
Version number13