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Cellosaurus TMC-1 (CVCL_9475)

[Text version]
Cell line name TMC-1
Synonyms TMC1
Accession CVCL_9475
Resource Identification Initiative To cite this cell line use: TMC-1 (RRID:CVCL_9475)
Comments Problematic cell line: Contaminated. Shown to be a SW480 (or SW620) derivative (BCRC=60379). Originally thought to originate from the lymph nodes of a 67 year old female patient with a gastric carcinoma.
Population: Caucasian.
Doubling time: ~15 hours (PubMed=15237194).
Omics: Deep quantitative proteome analysis.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0546 (SW480)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
Web pages http://www.bcrc.firdi.org.tw/attach/2019-05-28/a.pdf

PubMed=15237194; DOI=10.1159/000078426
Shyu R.-Y., Jiang S.-Y., Jong Y.-J., Cheng K.-C., Lin C.-H., Yu J.-C., Wu M.-F., Chang T.-M.
Establishment and characterization of a human gastric carcinoma cell line TMC-1.
Cells Tissues Organs 177:37-46(2004)

PubMed=17022644; DOI=10.1021/pr060212g
Chen Y.-R., Juan H.-F., Huang H.-C., Huang H.-H., Lee Y.-J., Liao M.-Y., Tseng C.-W., Lin L.-L., Chen J.-Y., Wang M.-J., Chen J.-H., Chen Y.-J.
Quantitative proteomic and genomic profiling reveals metastasis-related protein expression patterns in gastric cancer cells.
J. Proteome Res. 5:2727-2742(2006)

Cell line collections (Providers) BCRC; 60379 - Discontinued
Cell line databases/resources cancercelllines; CVCL_9475
Anatomy/cell type resources BTO; BTO:0003284
Encyclopedic resources Wikidata; Q54972678
Entry history
Entry creation06-Jun-2012
Last entry update30-Jan-2024
Version number17