Cellosaurus Caco-2 (CVCL_0025)
Cell line name | Caco-2 | ||||||||||||||||||||||||||||||||||||||||||||||
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Synonyms | CaCo-2; CACO-2; Caco 2; CACO 2; CACO2; CaCo2; CaCO2; Caco2; Caco-2/ATCC; Caco-II | ||||||||||||||||||||||||||||||||||||||||||||||
Accession | CVCL_0025 | ||||||||||||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: Caco-2 (RRID:CVCL_0025) | ||||||||||||||||||||||||||||||||||||||||||||||
Comments | Part of: AstraZeneca Colorectal cell line (AZCL) panel. Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: ENCODE project common cell types; tier 3. Part of: MD Anderson Cell Lines Project. Population: Caucasian. Virology: Highly susceptible to infection by SARS coronavirus (SARS-CoV) (PubMed=15316659; PubMed=15731278). Virology: Susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257; PubMed=34339474). Doubling time: 51.41 hours (PubMed=25944804); 3-4 days (ATCC=HTB-37); ~60-70 hours (CLS=300137); ~80 hours (DSMZ=ACC-169); ~32 hours (PBCF). Microsatellite instability: Stable (MSS) (PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746). Omics: CTCF ChIP-seq epigenome analysis. Omics: H3K27me3 ChIP-seq epigenome analysis. Omics: H3K36me3 ChIP-seq epigenome analysis. Omics: H3K4me3 ChIP-seq epigenome analysis. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep phosphoproteome analysis. Omics: Deep proteome analysis. Omics: miRNA expression profiling. Omics: N-glycan profiling. Omics: Protein expression by reverse-phase protein arrays. Omics: SNP array analysis. Omics: Transcriptome analysis by microarray. Omics: Transcriptome analysis by RNAseq. Omics: Transcriptome analysis by serial analysis of gene expression (SAGE). Derived from site: In situ; Colon; UBERON=UBERON_0001155. | ||||||||||||||||||||||||||||||||||||||||||||||
Sequence variations |
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HLA typing | Source: PubMed=25960936
Source: PubMed=26589293
Source: CLS=300137
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Genome ancestry | Source: PubMed=30894373
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Disease | Colon adenocarcinoma (NCIt: C4349) | ||||||||||||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||||||||||||||||
Hierarchy | Children:
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Sex of cell | Male | ||||||||||||||||||||||||||||||||||||||||||||||
Age at sampling | 72Y | ||||||||||||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio=C0009009/29; ATCC=HTB-37; CCRID; CLS=300137; DSMZ=ACC-169; ECACC=09042001; ECACC=86010202; PubMed=11416159; PubMed=25877200; PubMed=25926053; RCB=RCB0988 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||||||||||||
Web pages | https://en.wikipedia.org/wiki/Caco-2 https://www.atcc.org/en/support/technical-support/faqs/growth-rate-of-atcc-htb-37 https://www.atcc.org/en/support/technical-support/faqs/morphology-of-atcc-htb-37 https://www.proteinatlas.org/learn/cellines https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/caco-2/ https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-37.html https://www.cyprotex.com/admepk/in-vitro-permeability-and-drug-transporters/caco-2-permeability/ https://www.synapse.org/#!Synapse:syn31544480 https://tcpaportal.org/mclp/ | ||||||||||||||||||||||||||||||||||||||||||||||
Publications | PubMed=327080; DOI=10.1093/jnci/59.1.221 PubMed=833871; DOI=10.1093/jnci/58.2.209 PubMed=6935474; DOI=10.1093/jnci/66.2.239 PubMed=7459858 PubMed=3518877; DOI=10.3109/07357908609038260 PubMed=3349466 PubMed=2914637; DOI=10.1016/0016-5085(89)90897-4 PubMed=7764660; DOI=10.1007/BF00749813 PubMed=8253353; DOI=10.1016/0016-5085(93)91076-t PubMed=8508948; DOI=10.1111/j.1432-0436.1993.tb00645.x PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362 PubMed=10092214; DOI=10.1002/(SICI)1097-4652(199812)177:4<618::AID-JCP12>3.0.CO;2-R PubMed=10612807; DOI=10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P; PMCID=PMC4721570 PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243 PubMed=11414198; DOI=10.1007/s004320000207 PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459 PubMed=11668190; DOI=10.1177/002215540104901105 PubMed=12584437; DOI=10.1159/000068544 PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X PubMed=15316659; DOI=10.1007/s00018-004-4222-9; PMCID=PMC7079841 PubMed=15731278; DOI=10.1128/JVI.79.6.3846-3850.2005; PMCID=PMC1075706 PubMed=15868485; DOI=10.1007/s10565-005-0085-6 PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731 PubMed=16854228; DOI=10.1186/1476-4598-5-29; PMCID=PMC1550420 PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141 PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514 PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028 PubMed=20831567; DOI=10.1111/j.1582-4934.2010.01170.x; PMCID=PMC3918049 PubMed=21607810; DOI=10.1208/s12248-011-9283-8; PMCID=PMC3160153 PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849 PubMed=23932154; DOI=10.1016/j.radonc.2013.06.032 PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225 PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013 PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=25841592; DOI=10.1016/j.jprot.2015.03.019 PubMed=25877200; DOI=10.1038/nature14397 PubMed=25926053; DOI=10.1038/ncomms8002 PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457 PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878 PubMed=29787057; DOI=10.1007/978-3-319-16104-4_10 PubMed=26537799; DOI=10.1074/mcp.M115.051235; PMCID=PMC4762531 PubMed=26869432; DOI=10.1016/j.xphs.2015.10.030 PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076 PubMed=28683746; DOI=10.1186/s12943-017-0691-y; PMCID=PMC5498998 PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675 PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103 PubMed=31981602; DOI=10.1016/j.tiv.2020.104773 PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494 PubMed=34339474; DOI=10.1371/journal.pone.0255622; PMCID=PMC8328321 | ||||||||||||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||||||||||||
Cell line collections (Providers) | Abcam; ab275464 - Discontinued
AddexBio; C0009009/29 ATCC; HTB-37 BCRJ; 0059 CCTCC; GDC0153 CLS; 300137 DSMZ; ACC-169 ECACC; 09042001 ECACC; 86010202 IBRC; C10094 ICLC; HTL97023 IZSLER; BS TCL 87 KCB; KCB 200710YJ KCLB; 30037.1 NCBI_Iran; C139 RCB; RCB0988 Ubigene; YC-D003 | ||||||||||||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLO; CLO_0002172
CLO; CLO_0050627 MCCL; MCC:0000120 CLDB; cl614 CLDB; cl615 CLDB; cl616 CLDB; cl617 CLDB; cl618 CLDB; cl619 CLDB; cl621 CLDB; cl5174 cancercelllines; CVCL_0025 CCRID; 1101HUM-PUMC000100 CCRID; 1102HUM-NIFDC00087 CCRID; 3101HUMSCSP5027 CCRID; 3101HUMTCHu146 CCRID; 4201HUM-CCTCC00153 CCRID; 5301HUM-KCB07010YJ Cell_Model_Passport; SIDM00891 ColonAtlas; CACO2 DepMap; ACH-000003 DSMZCellDive; ACC-169 FCS-free; 192-2-378-1-3-3 LINCS_LDP; LCL-1170 Lonza; 36 TOKU-E; 762 | ||||||||||||||||||||||||||||||||||||||||||||||
Anatomy/cell type resources | BTO; BTO:0000195 | ||||||||||||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03473140
BioSample; SAMN05292461 BioSample; SAMN10989600 ENCODE; ENCBS311PHE ENCODE; ENCBS390JMI ENCODE; ENCBS391ENC ENCODE; ENCBS530YXL ENCODE; ENCBS700RKG ENCODE; ENCBS890JZY | ||||||||||||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307519
ChEMBL-Targets; CHEMBL614058 PharmacoDB; Caco2_161_2019 PubChem_Cell_line; CVCL_0025 | ||||||||||||||||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q5016050 | ||||||||||||||||||||||||||||||||||||||||||||||
Experimental variables resources | EFO; EFO_0001099 | ||||||||||||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-2706
GEO; GSM206450 GEO; GSM274711 GEO; GSM274712 GEO; GSM274725 GEO; GSM383861 GEO; GSM472900 GEO; GSM472933 GEO; GSM513908 GEO; GSM514182 GEO; GSM741244 GEO; GSM749689 GEO; GSM749691 GEO; GSM749748 GEO; GSM784006 GEO; GSM845394 GEO; GSM843481 GEO; GSM843482 GEO; GSM945162 GEO; GSM945203 GEO; GSM945206 GEO; GSM945236 GEO; GSM1006210 GEO; GSM1006211 GEO; GSM1006212 GEO; GSM1346866 GEO; GSM1374426 GEO; GSM1448160 GEO; GSM2549989 | ||||||||||||||||||||||||||||||||||||||||||||||
Medical resources | MeSH; D018938 | ||||||||||||||||||||||||||||||||||||||||||||||
Metabolomic databases | MetaboLights; MTBLS227
MetaboLights; MTBLS328 | ||||||||||||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 720340
Cosmic; 873696 Cosmic; 875297 Cosmic; 876709 Cosmic; 887244 Cosmic; 889531 Cosmic; 948127 Cosmic; 948829 Cosmic; 983736 Cosmic; 995392 Cosmic; 1043805 Cosmic; 1122320 Cosmic; 1132564 Cosmic; 1132694 Cosmic; 1184081 Cosmic; 1187299 Cosmic; 1310931 Cosmic; 1466811 Cosmic; 1479620 Cosmic; 1524334 Cosmic; 1552180 Cosmic; 1676742 Cosmic; 1708415 Cosmic; 1803940 Cosmic; 1933015 Cosmic; 2036652 Cosmic; 2145574 Cosmic; 2156940 Cosmic; 2301543 Cosmic; 2301964 Cosmic; 2667879 Cosmic; 2800568 IARC_TP53; 21749 Progenetix; CVCL_0025 | ||||||||||||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD001550
PRIDE; PXD005354 PRIDE; PXD005355 PRIDE; PXD018357 PRIDE; PXD019645 PRIDE; PXD023760 | ||||||||||||||||||||||||||||||||||||||||||||||
Sequence databases | EGA; EGAS00001000610
EGA; EGAS00001002554 | ||||||||||||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||||||||||||
Last entry update | 02-May-2024 | ||||||||||||||||||||||||||||||||||||||||||||||
Version number | 49 |