| Cell line name |
C2BBe2 |
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| Synonyms |
C2BBe 2; Caco-2/BBe 2; Caco-2 Brush Border expressing 2 |
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| Accession |
CVCL_Z582 |
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| Resource Identification Initiative |
To cite this cell line use: C2BBe2 (RRID:CVCL_Z582) |
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| Comments |
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0025 (Caco-2) |
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| Sex of cell |
Male |
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| Age at sampling |
72Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=1506435; DOI=10.1242/jcs.102.3.581
Peterson M.D., Mooseker M.S.
Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2.
J. Cell Sci. 102:581-600(1992) PubMed=15868485; DOI=10.1007/s10565-005-0085-6
Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., Zucco F.
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics.
Cell Biol. Toxicol. 21:1-26(2005) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_Z582
|
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| Encyclopedic resources |
Wikidata; Q54808118
|
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| Entry history |
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| Entry creation | 10-Apr-2015 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 14 |
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