| Cell line name |
Caco-2/3 |
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| Accession |
CVCL_Z578 |
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| Resource Identification Initiative |
To cite this cell line use: Caco-2/3 (RRID:CVCL_Z578) |
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| Comments |
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0025 (Caco-2) |
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| Sex of cell |
Male |
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| Age at sampling |
72Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=1764023; DOI=10.1042/bj2800599
Beaulieu J.-F., Quaroni A.
Clonal analysis of sucrase-isomaltase expression in the human colon adenocarcinoma Caco-2 cells.
Biochem. J. 280:599-608(1991) PubMed=15868485; DOI=10.1007/s10565-005-0085-6
Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., Zucco F.
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics.
Cell Biol. Toxicol. 21:1-26(2005) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_Z578
|
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| Encyclopedic resources |
Wikidata; Q54808323
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| Entry history |
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| Entry creation | 10-Apr-2015 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 12 |
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