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Cellosaurus Caco-2 CuSO4-R (CVCL_YP12)

[Text version]
Cell line name Caco-2 CuSO4-R
Synonyms CuSO4-R Caco-2; CuSO4-R
Accession CVCL_YP12
Resource Identification Initiative To cite this cell line use: Caco-2 CuSO4-R (RRID:CVCL_YP12)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_23414; Copper(II) sulfate.
Omics: Deep proteome analysis.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0025 (Caco-2)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=31981602; DOI=10.1016/j.tiv.2020.104773
O'Doherty C., Keenan J., Henry M., Meleady P., Sinkunaite I., Clynes M., O'Sullivan F., Horgan K., Murphy R.
Characterisation and proteomic profiling of continuously exposed Cu-resistant variants of the Caco-2 cell line.
Toxicol. In Vitro 65:104773.1-104773.14(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YP12
Encyclopedic resources Wikidata; Q93441263
Entry history
Entry creation12-Mar-2020
Last entry update19-Dec-2024
Version number9