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Cellosaurus Caco-2/15 (CVCL_0232)

[Text version]
Cell line name Caco-2/15
Synonyms Caco2/15
Accession CVCL_0232
Resource Identification Initiative To cite this cell line use: Caco-2/15 (RRID:CVCL_0232)
Comments Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0025 (Caco-2)
Children:
CVCL_Z585 (Caco-2/AQ)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=1764023; DOI=10.1042/bj2800599; PMCID=PMC1130497
Beaulieu J.-F., Quaroni A.
Clonal analysis of sucrase-isomaltase expression in the human colon adenocarcinoma Caco-2 cells.
Biochem. J. 280:599-608(1991)

PubMed=9827699; DOI=10.1002/(SICI)1097-4644(19981215)71:4<536::AID-JCB8>3.0.CO;2-1
Desloges N., Basora N., Perreault N., Bouatrouss Y., Sheppard D., Beaulieu J.-F.
Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation.
J. Cell. Biochem. 71:536-545(1998)

PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X
Ranaldi G., Consalvo R., Sambuy Y., Scarino M.L.
Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media.
Toxicol. In Vitro 17:761-767(2003)

PubMed=15868485; DOI=10.1007/s10565-005-0085-6
Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., Zucco F.
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics.
Cell Biol. Toxicol. 21:1-26(2005)

Cross-references
Cell line databases/resources MCCL; MCC:0000121
cancercelllines; CVCL_0232
Anatomy/cell type resources BTO; BTO_0005279
Encyclopedic resources Wikidata; Q54808322
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number20