Cell line name |
Caco-2/15 |
Synonyms |
Caco2/15 |
Accession |
CVCL_0232 |
Resource Identification Initiative |
To cite this cell line use: Caco-2/15 (RRID:CVCL_0232) |
Comments |
Population: Caucasian. Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0025 (Caco-2) Children:
|
Sex of cell |
Male |
Age at sampling |
72Y |
Category |
Cancer cell line |
Publications | PubMed=1764023; DOI=10.1042/bj2800599; PMCID=PMC1130497 Beaulieu J.-F., Quaroni A. Clonal analysis of sucrase-isomaltase expression in the human colon adenocarcinoma Caco-2 cells. Biochem. J. 280:599-608(1991) PubMed=9827699; DOI=10.1002/(SICI)1097-4644(19981215)71:4<536::AID-JCB8>3.0.CO;2-1 Desloges N., Basora N., Perreault N., Bouatrouss Y., Sheppard D., Beaulieu J.-F. Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation. J. Cell. Biochem. 71:536-545(1998) PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X Ranaldi G., Consalvo R., Sambuy Y., Scarino M.L. Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media. Toxicol. In Vitro 17:761-767(2003) PubMed=15868485; DOI=10.1007/s10565-005-0085-6 Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., Zucco F. The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biol. Toxicol. 21:1-26(2005) |
Cross-references |
Cell line databases/resources |
MCCL; MCC:0000121
cancercelllines; CVCL_0232
|
Anatomy/cell type resources |
BTO; BTO_0005279
|
Encyclopedic resources |
Wikidata; Q54808322
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 19-Dec-2024 |
Version number | 20 |
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