Cellosaurus cell line Abcam Caco-2 ACE2 KO (CVCL

Cross-references
Cell line name	Abcam Caco-2 ACE2 KO
Synonyms	Human ACE2 knockout Caco-2
Accession	CVCL_B0YL
Resource Identification Initiative	To cite this cell line use: Abcam Caco-2 ACE2 KO (RRID:CVCL_B0YL)
Comments	Group: SARS-CoV-2 research cell line. Population: Caucasian. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:13557; ACE2. Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations	Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease	Colon adenocarcinoma (NCIt: C4349)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0025 (Caco-2)
Sex of cell	Male
Age at sampling	72Y
Category	Cancer cell line
Cell line collections (Providers)	Abcam; ab273731
Cell line databases/resources	cancercelllines; CVCL_B0YL
Encyclopedic resources	Wikidata; Q110430389
Entry history
Entry creation	16-Dec-2021
Last entry update	19-Dec-2024
Version number	7