Cell line name |
Caco-2/TC-7 |
Synonyms |
Caco-2/TC7; Caco2/TC7; TC-7; TC7 |
Accession |
CVCL_0233 |
Resource Identification Initiative |
To cite this cell line use: Caco-2/TC-7 (RRID:CVCL_0233) |
Comments |
Population: Caucasian. Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0025 (Caco-2) |
Sex of cell |
Male |
Age at sampling |
72Y |
Category |
Cancer cell line |
STR profile |
Source(s): Millipore=SCC209
Markers: Run an STR similarity search on this cell line |
Publications | PubMed=8175910; DOI=10.1242/jcs.107.1.213 Chantret I., Rodolosse A., Barbat A., Dussaulx E., Brot-Laroche E., Zweibaum A., Rousset M. Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: evidence for glucose-dependent negative regulation. J. Cell Sci. 107:213-225(1994) DOI=10.1016/0378-5173(94)00280-I Caro I., Boulenc X., Rousset M., Meunier V., Bourrie M., Julian B., Joyeux H., Roques C., Berger Y., Zweibaum A., Fabre G. Characterisation of a newly isolated Caco-2 clone (TC-7), as a model of transport processes and biotransformation of drugs. Int. J. Pharm. 116:147-158(1995) PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X Ranaldi G., Consalvo R., Sambuy Y., Scarino M.L. Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media. Toxicol. In Vitro 17:761-767(2003) PubMed=15868485; DOI=10.1007/s10565-005-0085-6 Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., Zucco F. The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biol. Toxicol. 21:1-26(2005) |
Cross-references |
Cell line collections (Providers) |
Millipore; SCC209
|
Cell line databases/resources |
MCCL; MCC:0000122
cancercelllines; CVCL_0233
ColonAtlas; TC7
Lonza; 1105
|
Anatomy/cell type resources |
BTO; BTO_0002571
|
Chemistry resources |
ChEMBL-Cells; CHEMBL4483155
ChEMBL-Targets; CHEMBL4483233
PubChem_Cell_line; CVCL_0233
|
Encyclopedic resources |
Wikidata; Q54808328
|
Experimental variables resources |
EFO; EFO_0002817
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 19-Dec-2024 |
Version number | 24 |
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