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Cellosaurus Caco-2MT (CVCL_C8JJ)

[Text version]
Cell line name Caco-2MT
Accession CVCL_C8JJ
Resource Identification Initiative To cite this cell line use: Caco-2MT (RRID:CVCL_C8JJ)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03077; Murine polyomavirus (strain A2) (MPyV) middle T antigen (PyMT).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 10636; Murine polyomavirus (strain A2) (MPyV).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0025 (Caco-2)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=8253353; DOI=10.1016/0016-5085(93)91076-t
Chastre E., Empereur S., Di Gioia Y., El Mahdani N., Mareel M.M., Vleminckx K.L., Van Roy F.M., Bex V., Emami S., Spandidos D.A., Gespach C.
Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes.
Gastroenterology 105:1776-1789(1993)

Cross-references
Encyclopedic resources Wikidata; Q123030848
Entry history
Entry creation05-Oct-2023
Last entry update19-Dec-2024
Version number4