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Cellosaurus Caco-2T (CVCL_C8JK)

[Text version]
Cell line name Caco-2T
Accession CVCL_C8JK
Resource Identification Initiative To cite this cell line use: Caco-2T (RRID:CVCL_C8JK)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0025 (Caco-2)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=8253353; DOI=10.1016/0016-5085(93)91076-t
Chastre E., Empereur S., Di Gioia Y., El Mahdani N., Mareel M.M., Vleminckx K.L., Van Roy F.M., Bex V., Emami S., Spandidos D.A., Gespach C.
Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes.
Gastroenterology 105:1776-1789(1993)

Cross-references
Encyclopedic resources Wikidata; Q123030849
Entry history
Entry creation05-Oct-2023
Last entry update19-Dec-2024
Version number4