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Cellosaurus betaG I/17 (CVCL_C1JU)

[Text version]
Cell line name betaG I/17
Synonyms betaG 1/17; BG I/17
Accession CVCL_C1JU
Resource Identification Initiative To cite this cell line use: betaG I/17 (RRID:CVCL_C1JU)
Comments Characteristics: Transfected with a pCB6-INS-Neo construct. Expresses 10 times more insulin than the parent cell line (PubMed=9166666).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS:0000603.
Hierarchy Parent: CVCL_U435 (RIN 1046-38)
Children:
CVCL_C1JV (betaG 11/3E9)CVCL_C1JW (betaG 23/21)CVCL_C1JX (betaG 40/107)
CVCL_C1JZ (betaG 40/110)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Publications

PubMed=9166666; DOI=10.2337/diab.46.6.958
Clark S.A., Quaade C., Constandy H., Hansen P., Halban P.A., Ferber S., Newgard C.B., Normington K.
Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression.
Diabetes 46:958-967(1997)

PubMed=9166667; DOI=10.2337/diab.46.6.968
Hohmeier H.-E., BeltrandelRio H., Clark S.A., Henkel-Rieger R., Normington K., Newgard C.B.
Regulation of insulin secretion from novel engineered insulinoma cell lines.
Diabetes 46:968-977(1997)

Cross-references
Encyclopedic resources Wikidata; Q114310746
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6