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Cellosaurus betaG 11/3E9 (CVCL_C1JV)

[Text version]
Cell line name betaG 11/3E9
Synonyms betaG11/3E9
Accession CVCL_C1JV
Resource Identification Initiative To cite this cell line use: betaG 11/3E9 (RRID:CVCL_C1JV)
Comments Characteristics: Transfected with both a pCB6-INS-Neo and a pRIP7-INS-HygroR constructs. Expresses 27 times more insulin than the grand-parent cell line (PubMed=9166666).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS:0000603.
Hierarchy Parent: CVCL_C1JU (betaG I/17)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Publications

PubMed=9166666; DOI=10.2337/diab.46.6.958
Clark S.A., Quaade C., Constandy H., Hansen P., Halban P.A., Ferber S., Newgard C.B., Normington K.
Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression.
Diabetes 46:958-967(1997)

Cross-references
Encyclopedic resources Wikidata; Q114310739
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number7