Cellosaurus HEp-2 (CVCL_1906)
Cell line name | HEp-2 | ||||||||||||||||||||||||||||||||||||
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Synonyms | Hep-2; HEP-2; Hep2 (HeLa derivative); HEp-2/HeLa; Hep 2; Hep2; HEp2; HEP2; H.Ep.-2; H.Ep. #2; H.Ep. No. 2; Hep II; Human Epidermoid carcinoma #2; Human Epithelioma-2 | ||||||||||||||||||||||||||||||||||||
Accession | CVCL_1906 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: HEp-2 (RRID:CVCL_1906) | ||||||||||||||||||||||||||||||||||||
Comments | Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=566722; PubMed=1246601; PubMed=20143388). Originally thought to originate from a 56 year old male patient with a laryngeal carcinoma. Part of: KuDOS 95 cell line panel. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00007. Population: African American. Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257). Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Omics: Genome sequenced (low read coverage). Omics: SNP array analysis. Omics: Transcriptome analysis by microarray. Omics: Transcriptome analysis by RNAseq. Omics: Ubiquitination analysis by proteomics. Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002. | ||||||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=26589293
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Disease | Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677) | ||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||||||
Hierarchy | Parent: CVCL_0030 (HeLa) Children:
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Sex of cell | Female | ||||||||||||||||||||||||||||||||||||
Age at sampling | 30Y6M | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio=C0050001/4983; ATCC=CCL-23; CCRID; CLS=300397; KCLB=10023; PubMed=11416159; PubMed=17254797; RCB=RCB1889; TKG=TKG 0403 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-204.html https://en.vircell.com/products/hep-2-cell-line/ https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx https://es.wikipedia.org/wiki/C%C3%A9lulas_HEp-2 | ||||||||||||||||||||||||||||||||||||
Publications | PubMed=13209540 PubMed=13261081 PubMed=14185313; DOI=10.1126/science.146.3641.241 PubMed=4864103 PubMed=5641128; DOI=10.1038/217750a0 PubMed=5668122; DOI=10.3181/00379727-128-33119 DOI=10.1007/BF02618370 PubMed=4203458 DOI=10.1007/978-1-4757-1647-4_13 PubMed=1246601; DOI=10.1126/science.1246601 PubMed=566722; DOI=10.1007/BF02616110 PubMed=6988327; DOI=10.1007/BF02831503 PubMed=3180844; DOI=10.1159/000132579 PubMed=8397027 DOI=10.11418/jtca1981.17.3_95 PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459 PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001 PubMed=19450234; DOI=10.2144/000113089; PMCID=PMC2696096 PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022 PubMed=20143388; DOI=10.1002/ijc.25242 PubMed=23925245; DOI=10.1038/nature12064; PMCID=PMC3740412 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878 CLPUB00484 PubMed=29483928; DOI=10.1186/s11658-017-0067-8; PMCID=PMC5819209 PubMed=29967540; DOI=10.1038/s41594-018-0084-y PubMed=31105993; PMCID=PMC6511639 PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494 PubMed=34024160; DOI=10.2144/btn-2020-0162 PubMed=34697958; DOI=10.1177/24725552211051963 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections (Providers) | AddexBio; C0050001/4983
ATCC; CCL-23 BCRC; 60042 - Discontinued BCRJ; 0101 CCLV; CCLV-RIE 0141 CCTCC; GDC0004 CLS; 300397 ECACC; 86030501 IZSLER; BS TCL 23 KCLB; 10023 NCBI_Iran; C144 RCB; RCB1889 TKG; TKG 0403 | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLO; CLO_0003706
CLO; CLO_0003707 CLO; CLO_0050927 CLDB; cl1646 CLDB; cl1647 CLDB; cl1649 CLDB; cl1650 CLDB; cl1653 CLDB; cl1654 CLDB; cl1655 CCRID; 1101HUM-PUMC000068 CCRID; 4201PAT-CCTCC00214 Cell_Model_Passport; SIDM01208 TOKU-E; 1442 | ||||||||||||||||||||||||||||||||||||
Anatomy/cell type resources | BTO; BTO:0000976 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03151706 | ||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307694
ChEMBL-Targets; CHEMBL614735 PharmacoDB; HEp2_540_2019 PubChem_Cell_line; CVCL_1906 | ||||||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q16554737 | ||||||||||||||||||||||||||||||||||||
Experimental variables resources | EFO; EFO_0006438 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-2706
GEO; GSM1374529 GEO; GSM1374530 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 1339928
Cosmic; 1530739 Cosmic; 1969495 Cosmic; 2301559 | ||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD006201
PRIDE; PXD013072 PRIDE; PXD014913 PRIDE; PXD031726 | ||||||||||||||||||||||||||||||||||||
Sequence databases | EGA; EGAS00001000610 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry update | 02-May-2024 | ||||||||||||||||||||||||||||||||||||
Version number | 41 |