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Cellosaurus HEp2-Mx2/EGFP L1G5 (CVCL_RX05)

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Cell line name HEp2-Mx2/EGFP L1G5
Synonyms HEp L1G5; L1G5
Accession CVCL_RX05
Resource Identification Initiative To cite this cell line use: HEp2-Mx2/EGFP L1G5 (RRID:CVCL_RX05)
Comments Problematic cell line: Contaminated. Parent cell line (HEp-2) has been shown to be a HeLa derivative.
Population: African American.
Biotechnology: Used for a reporter gene assay (RGA) of the human type 1 interferon potency (PubMed=27346232).
Characteristics: Expression of eGFP is under the control of the control of the mouse Mx2 promoter (PubMed=27346232).
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1906 (HEp-2)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line

PubMed=22373148; DOI=10.1186/1753-6561-5-S8-P4
Burgi M., Prieto C., Oggero M., Bollati-Fogolin M., Etcheverrigaray M., Kratje R.
New reporter cell clones to determine the biological activity of human type I interferons.
BMC Proc. 5 Suppl. 8:P4-P4(2011)

PubMed=27346232; DOI=10.1016/j.jbiotec.2016.06.021
Burgi M., Zapol'skii V.A., Hinkelmann B., Koster M., Kaufmann D.E., Sasse F., Hauser H., Etcheverrigaray M., Kratje R., Bollati-Fogolin M., Oggero M.
Screening and characterization of molecules that modulate the biological activity of IFNs-I.
J. Biotechnol. 233:6-16(2016)

Encyclopedic resources Wikidata; Q54882751
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number7