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Cellosaurus HL-CZ (CVCL_WU73)

[Text version]
Cell line name HL-CZ
Accession CVCL_WU73
Resource Identification Initiative To cite this cell line use: HL-CZ (RRID:CVCL_WU73)
Comments Problematic cell line: Contaminated. Shown to be a K-562 derivative (BCRC=60043). Originally thought to originate from a 50 year old male patient with a acute T-cell leukemia.
Population: Caucasian.
Doubling time: 22-26 hours (CelloPub=CLPUB00515).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Web pages http://www.bcrc.firdi.org.tw/attach/2019-05-28/a.pdf

Liu W.-T., Chen S.-C., Lee N., Tan S.-K., Liu S.-F., Dunn P., Chang K.S.-S.
Establishment and characterization of a cell line of monocytic origin, HL-CZ, from human leukemia.
J. Biomed. Lab. Sci. 4:284-292(1989)

PubMed=1913629; DOI=10.1016/0304-3835(91)90051-I
Chang K.S.-S., Liu W.-T., Josephs S.F.
Regulation of cellular trans-activating activities in two different promonocytic leukemia cell lines.
Cancer Lett. 60:75-83(1991)

PubMed=2063953; DOI=10.4269/ajtmh.1991.44.494
Liu W.-T., Chen C.-L., Lee S.S.-J., Chan C.-C., Lo F.-L., Ko Y.-C.
Isolation of dengue virus with a human promonocyte cell line.
Am. J. Trop. Med. Hyg. 44:494-499(1991)

Lieu C.-W., Liu W.-T., Sun K.-H., Wang S.-Y.
Some special characteristics of the novel human promonocyte cell line, HL-CZ.
J. Biomed. Lab. Sci. 5:196-204(1993)

Cheng X.-H.
Screening for differentially expressed genes in dengue infection under antibody dependent enhancement conditions.
Thesis MSc (2010), National University of Singapore, Singapore

PubMed=25073113; DOI=10.1016/j.bbrc.2014.07.090
Wang S.-F., Tseng S.-P., Yen C.-H., Yang J.-Y., Tsao C.-H., Shen C.-W., Chen K.-H., Liu F.-T., Liu W.-T., Chen Y.-M.A., Huang J.C.
Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins.
Biochem. Biophys. Res. Commun. 451:208-214(2014)

Cell line collections (Providers) BCRC; 60043 - Discontinued
Encyclopedic resources Wikidata; Q94211712
Entry history
Entry creation05-Jul-2019
Last entry update30-Jan-2024
Version number11