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Cellosaurus publication CLPUB00515

Publication number CLPUB00515
Authors Liu W.-T., Chen S.-C., Lee N., Tan S.-K., Liu S.-F., Dunn P., Chang K.S.-S.
Title Establishment and characterization of a cell line of monocytic origin, HL-CZ, from human leukemia.
Citation J. Biomed. Lab. Sci. 4:284-292(1989)
Web pages http://readopac3.ncl.edu.tw/nclserialFront/search/detail.jsp?sysId=0005305277&dtdId=000040&search_type=detail&la=ch
Abstract A cell line of monocytic origin named HL-CZ has been established in long- term culture from a 50-year-old Chinese male with adult T-cell leukemia. The cell size in this culture is mostly 16 mum (with a range of 12-30 mum) in diameter. The doubling time of the cell is 22-26 hrs. The light microscopy and electron microscopy of the cells show that these monocytic cells are phagocytic, with single, double or multiple nuclei. Abundant basophilic cytoplasm is one of the characteristics of the cells. Since more than 90% of the cells possess CD 15 marker and show early differentiation in hematopoiesis, it is designated as a population of promonocyte, The chromosome number of each cell varies from 41 to 75 with fragment aberration in 91% and the other with isochromatin break and gap. Some detailed analysis of the cell markers and complicated chromosome pictures remain for further studies.
Cell lines CVCL_WU73; HL-CZ