ID   HL-CZ
AC   CVCL_WU73
DR   BCRC; 60043
DR   Wikidata; Q94211712
RX   CelloPub=CLPUB00514;
RX   CelloPub=CLPUB00515;
RX   CelloPub=CLPUB00516;
RX   PubMed=1913629;
RX   PubMed=2063953;
RX   PubMed=25073113;
WW   http://www.bcrc.firdi.org.tw/attach/2019-05-28/a.pdf
CC   Problematic cell line: Contaminated. Shown to be a K-562 derivative (BCRC=60043). Originally thought to originate from a 50 year old male patient with a acute T-cell leukemia.
CC   Population: Caucasian.
CC   Doubling time: 22-26 hours (CelloPub=CLPUB00515).
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
CC   Discontinued: BCRC; 60043; true.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0004 ! K-562
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 30-01-24; Version: 11
//
RX   CelloPub=CLPUB00514;
RA   Cheng X.-H.;
RT   "Screening for differentially expressed genes in dengue infection under
RT   antibody dependent enhancement conditions.";
RL   Thesis MSc (2010), National University of Singapore, Singapore.
//
RX   CelloPub=CLPUB00515;
RA   Liu W.-T., Chen S.-C., Lee N., Tan S.-K., Liu S.-F., Dunn P.,
RA   Chang K.S.-S.;
RT   "Establishment and characterization of a cell line of monocytic origin,
RT   HL-CZ, from human leukemia.";
RL   J. Biomed. Lab. Sci. 4:284-292(1989).
//
RX   CelloPub=CLPUB00516;
RA   Lieu C.-W., Liu W.-T., Sun K.-H., Wang S.-Y.;
RT   "Some special characteristics of the novel human promonocyte cell
RT   line, HL-CZ.";
RL   J. Biomed. Lab. Sci. 5:196-204(1993).
//
RX   PubMed=1913629; DOI=10.1016/0304-3835(91)90051-I;
RA   Chang K.S.-S., Liu W.-T., Josephs S.F.;
RT   "Regulation of cellular trans-activating activities in two different
RT   promonocytic leukemia cell lines.";
RL   Cancer Lett. 60:75-83(1991).
//
RX   PubMed=2063953; DOI=10.4269/ajtmh.1991.44.494;
RA   Liu W.-T., Chen C.-L., Lee S.S.-J., Chan C.-C., Lo F.-L., Ko Y.-C.;
RT   "Isolation of dengue virus with a human promonocyte cell line.";
RL   Am. J. Trop. Med. Hyg. 44:494-499(1991).
//
RX   PubMed=25073113; DOI=10.1016/j.bbrc.2014.07.090;
RA   Wang S.-F., Tseng S.-P., Yen C.-H., Yang J.-Y., Tsao C.-H., Shen C.-W.,
RA   Chen K.-H., Liu F.-T., Liu W.-T., Chen Y.-M.A., Huang J.C.;
RT   "Antibody-dependent SARS coronavirus infection is mediated by
RT   antibodies against spike proteins.";
RL   Biochem. Biophys. Res. Commun. 451:208-214(2014).
//