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Cellosaurus MCF10AT1k.cl2 (CVCL_WM98)

[Text version]
Cell line name MCF10AT1k.cl2
Synonyms MCF10AT1KCl.2; MCF10AT1K
Accession CVCL_WM98
Resource Identification Initiative To cite this cell line use: MCF10AT1k.cl2 (RRID:CVCL_WM98)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: Deep proteome analysis.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5554 (MCF-10A-neoT)
Children:
CVCL_6675 (MCF10CA1a)CVCL_6677 (MCF10CA1b)CVCL_6678 (MCF10CA1c)
CVCL_6679 (MCF10CA1d)CVCL_6683 (MCF10CA1h)
Sex of cell Female
Age at sampling 36Y
Category Transformed cell line
Publications

PubMed=11261825; DOI=10.1023/A:1006461422273
Santner S.J., Dawson P.J., Tait L., Soule H.D., Eliason J.F., Mohamed A.N., Wolman S.R., Heppner G.H., Miller F.R.
Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells.
Breast Cancer Res. Treat. 65:101-110(2001)

PubMed=14523048; DOI=10.1172/JCI18899; PMCID=PMC198530
Tang B.-W., Vu M., Booker T., Santner S.J., Miller F.R., Anver M.R., Wakefield L.M.
TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.
J. Clin. Invest. 112:1116-1124(2003)

PubMed=20543960; DOI=10.1371/journal.pone.0011030; PMCID=PMC2882958
Choong L.Y., Lim S., Chong P.K., Wong C.Y., Shah N., Lim Y.P.
Proteome-wide profiling of the MCF10AT breast cancer progression model.
PLoS ONE 5:E11030-E11030(2010)

Cross-references
Encyclopedic resources Wikidata; Q95986693
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number10