Cellosaurus cell line ELD-1 (CVCL

Cellosaurus ELD-1 (CVCL_VN20)

[Text version]

Cell line name

ELD-1

Accession

CVCL_VN20

Resource Identification Initiative

To cite this cell line use: ELD-1 (RRID:CVCL_VN20)

Comments

Problematic cell line: Contaminated. Grand-parent cell line (MOBS-1) has been shown to be a U-937 derivative.
Population: Caucasian.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).

Disease

Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_RX32 (MABS-1)
Children:

CVCL_VN21 (ELD-1 C-11)

CVCL_VN22 (ELD-1 C-8)

CVCL_VN23 (ELD-1 D-9)

Sex of cell

Male

Age at sampling

37Y