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Cellosaurus MABS-1 (CVCL_RX32)

[Text version]
Cell line name MABS-1
Accession CVCL_RX32
Resource Identification Initiative To cite this cell line use: MABS-1 (RRID:CVCL_RX32)
Comments Problematic cell line: Contaminated. Parent cell line (MOBS-1) has been shown to be a U-937 derivative.
Population: Caucasian.
Doubling time: 20 hours (DOI=10.15369/sujms1989.9.45).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8442 (MOBS-1)
Children:
CVCL_VN20 (ELD-1)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Publications

DOI=10.15369/sujms1989.9.45
Matsuda I., Iwamoto S., Aoki K., Matsumoto M., Shibuya I., Hagiwara T., Tsuruoka N., Takeda M., Okamoto K.
Establishment of a novel human macrophage-like cell line, MABS-1, derived from a human monocytic leukemia cell line, MOBS-1.
Showa Univ. J. Med. Sci. 9:45-55(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RX32
Encyclopedic resources Wikidata; Q54903939
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number11