Cell line name |
ELD-1 C-8 |
Synonyms |
ELD-1 subclone C-8; C-8 |
Accession |
CVCL_VN22 |
Resource Identification Initiative |
To cite this cell line use: ELD-1 C-8 (RRID:CVCL_VN22) |
Comments |
Problematic cell line: Contaminated. Ancestral cell line (MOBS-1) has been shown to be a U-937 derivative. Population: Caucasian. Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_VN20 (ELD-1) |
Sex of cell |
Male |
Age at sampling |
37Y |
Category |
Cancer cell line |
Publications | DOI=10.14930/jsma1939.62.310 Tamaoki S., Iwamoto S., Ishida M., Sugisaki K., Nakamura K. Roles of cytokines in interferon-gamma; generation by allogeneic response between CD8 T cells and a human dendritic cell-like cell line, ELD-1 -- a model of study for CD8 T cell promotion independent helper T cells. Showa Igakkai Zasshi 62:310-320(2002) PubMed=15922715; DOI=10.1016/j.cellimm.2005.01.008 Iwamoto S., Ishida M., Tamaoki S., Hagiwara T., Sueki H., Miyazaki A. A human Langerhans cell-like cell line, ELD-1, promotes CD8 T cells to produce IFN-gamma through CD70-dependent alternative pathway. Cell. Immunol. 232:49-56(2004) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_VN22
|
Encyclopedic resources |
Wikidata; Q93539956
|
Entry history |
Entry creation | 07-Sep-2018 |
Last entry update | 05-Oct-2023 |
Version number | 10 |
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