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Cellosaurus V79-hCYP1A2 (CVCL_4V39)

[Text version]
Cell line name V79-hCYP1A2
Synonyms V79-CYP1A2; V79MZh1A2; XEMhIA2-MZ#1; XEMh1A2-MZ*1; XEMhIA2-MZ
Accession CVCL_4V39
Resource Identification Initiative To cite this cell line use: V79-hCYP1A2 (RRID:CVCL_4V39)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2596; CYP1A2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_4V36 (V79MZ)
Children:
CVCL_A2GZ (V79-hCYP1A2-hNAT1)CVCL_A2HA (V79-hCYP1A2-hNAT2)CVCL_A2GY (V79-hCYP1A2-hSULT1A1)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=1446722; DOI=10.1016/0926-6917(92)90017-7
Wolfel C., Heinrich-Hirsch B., Schulz-Schalge T., Seidel A., Frank H., Ramp U., Wachter F., Wiebel F.J., Gonzalez F.J., Greim H., Doehmer J.
Genetically engineered V79 Chinese hamster cells for stable expression of human cytochrome P450IA2.
Eur. J. Pharmacol. 228:95-102(1992)

PubMed=8293790; DOI=10.1016/0926-6917(93)90052-R
Schmalix W.A., Maser H., Kiefer F., Reen R., Wiebel F.J., Gonzalez F.J., Seidel A., Glatt H.-R., Greim H., Doehmer J.
Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene.
Eur. J. Pharmacol. 248:251-261(1993)

PubMed=31112310; DOI=10.1002/em.22309
Zhu N., Hu K.-Q., Li Z.-H., Chen Y.-T., Liu Y.-G.
Micronuclei formation by promutagens in metabolism-incompetent V79 cells interacting with activation-proficient cells in various experimental settings.
Environ. Mol. Mutagen. 61:224-234(2020)

Cross-references
Encyclopedic resources Wikidata; Q54992632
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number11