ID   V79-hCYP1A2
AC   CVCL_4V39
SY   V79-CYP1A2; V79MZh1A2; XEMhIA2-MZ#1; XEMh1A2-MZ*1; XEMhIA2-MZ
DR   Wikidata; Q54992632
RX   PubMed=1446722;
RX   PubMed=8293790;
RX   PubMed=31112310;
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2596; CYP1A2.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_4V36 ! V79MZ
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 14-12-15; Last updated: 10-09-24; Version: 10
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RX   PubMed=1446722; DOI=10.1016/0926-6917(92)90017-7;
RA   Wolfel C., Heinrich-Hirsch B., Schulz-Schalge T., Seidel A., Frank H.,
RA   Ramp U., Wachter F., Wiebel F.J., Gonzalez F.J., Greim H., Doehmer J.;
RT   "Genetically engineered V79 Chinese hamster cells for stable
RT   expression of human cytochrome P450IA2.";
RL   Eur. J. Pharmacol. 228:95-102(1992).
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RX   PubMed=8293790; DOI=10.1016/0926-6917(93)90052-R;
RA   Schmalix W.A., Maser H., Kiefer F., Reen R., Wiebel F.J.,
RA   Gonzalez F.J., Seidel A., Glatt H.-R., Greim H., Doehmer J.;
RT   "Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese
RT   hamster cells and metabolic activation of benzo[a]pyrene.";
RL   Eur. J. Pharmacol. 248:251-261(1993).
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RX   PubMed=31112310; DOI=10.1002/em.22309;
RA   Zhu N., Hu K.-Q., Li Z.-H., Chen Y.-T., Liu Y.-G.;
RT   "Micronuclei formation by promutagens in metabolism-incompetent V79
RT   cells interacting with activation-proficient cells in various
RT   experimental settings.";
RL   Environ. Mol. Mutagen. 61:224-234(2020).
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