| Cell line name |
E006AA |
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| Synonyms |
E006AA-Par; E006AA-Pr |
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| Accession |
CVCL_4834 |
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| Resource Identification Initiative |
To cite this cell line use: E006AA (RRID:CVCL_4834) |
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| Comments |
Problematic cell line: Contaminated. Shown to be a 786-O derivative (PubMed=31416301). Originally thought to originate from a 50 year old patient with prostate carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00585.
Population: Caucasian.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113. |
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| Sequence variations |
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; c.560-2A>G; ClinVar=VCV003148158; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
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| Disease |
Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1051 (786-O)
Children:
|
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| Sex of cell |
Male |
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| Age at sampling |
58Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): Millipore=SCC102
Markers:
Run an STR similarity search on this cell line |
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| Web pages |
https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx |
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| Publications | PubMed=15162380; DOI=10.1002/pros.20053
Koochekpour S., Maresh G.A., Katner A., Parker-Johnson K., Lee T.-J., Hebert F.E., Kao Y.S., Skinner J., Rayford W.
Establishment and characterization of a primary androgen-responsive African-American prostate cancer cell line, E006AA.
Prostate 60:141-152(2004) PubMed=25076860; DOI=10.7150/ijbs.9406; PMCID=PMC4115195
Koochekpour S., Willard S.S., Shourideh M., Ali S., Liu C.-H., Azabdaftari G., Saleem M., Attwood K.M.
Establishment and characterization of a highly tumorigenic African American prostate cancer cell line, E006AA-hT.
Int. J. Biol. Sci. 10:834-845(2014) CLPUB00549
Moore J.C.
Establishment Of CRISPR/Cas-9 aided knockout of the ZIC2 gene in the African-American prostate cancer cell line E006AA-PR.
Thesis MSc (2019); Clark Atlanta University; Atlanta; USA PubMed=31416301; DOI=10.1002/pros.23800
Koochekpour S., Maresh G.A., Katner A., Parker-Johnson K., Lee T.-J., Hebert F.E., Kao Y.S., Skinner J., Rayford W.
Correction: Establishment and characterization of a primary androgen-responsive African-American prostate cancer cell line, E006AA. Prostate 2004;60(2):145-152.
Prostate 79:815-815(2019) |
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| Cross-references |
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| Cell line collections (Providers) |
Millipore; SCC102 - Discontinued
|
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| Cell line databases/resources |
cancercelllines; CVCL_4834
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| Encyclopedic resources |
Wikidata; Q38514722
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 22 |
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