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Cellosaurus E006AA ZIC2-/- G12 (CVCL_YI82)

[Text version]
Cell line name E006AA ZIC2-/- G12
Accession CVCL_YI82
Resource Identification Initiative To cite this cell line use: E006AA ZIC2-/- G12 (RRID:CVCL_YI82)
Comments Problematic cell line: Contaminated. Parent cell line (E006AA) has been shown to be a 786-O derivative.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 12873; ZIC2.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.560-2A>G; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4834 (E006AA)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line

Moore J.C.
Establishment Of CRISPR/Cas-9 aided knockout of the ZIC2 gene in the African-American prostate cancer cell line E006AA-PR.
Thesis MSc (2019), Clark Atlanta University, United States

Cell line databases/resources cancercelllines; CVCL_YI82
Encyclopedic resources Wikidata; Q93534059
Entry history
Entry creation19-Dec-2019
Last entry update05-Oct-2023
Version number9