Cell line name |
E006AA-hT |
Synonyms |
E006AA-highly Tumorigenic |
Accession |
CVCL_X480 |
Resource Identification Initiative |
To cite this cell line use: E006AA-hT (RRID:CVCL_X480) |
Comments |
Problematic cell line: Contaminated. Parent cell line (E006AA) has been shown to be a 786-O derivative. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00586. Population: Caucasian. Derived from sampling site: Kidney. |
Sequence variations |
- Mutation; HGNC; 9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; c.560-2A>G; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
|
Disease |
Renal cell carcinoma (NCIt: C9385) Renal cell carcinoma (ORDO: Orphanet_217071) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_4834 (E006AA) |
Sex of cell |
Male |
Age at sampling |
58Y |
Category |
Cancer cell line |
STR profile |
Source(s): ATCC
Markers: Run an STR similarity search on this cell line |
Web pages |
https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx |
Publications | PubMed=25076860; DOI=10.7150/ijbs.9406 Koochekpour S., Willard S.S., Shourideh M., Ali S., Liu C.-H., Azabdaftari G., Saleem M., Attwood K. Establishment and characterization of a highly tumorigenic African American prostate cancer cell line, E006AA-hT. Int. J. Biol. Sci. 10:834-845(2014) PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132 Hooker S.E. Jr., Woods-Burnham L., Bathina M., Lloyd S.M., Gorjala P., Mitra R., Nonn L., Kimbro K.S., Kittles R. Genetic ancestry analysis reveals misclassification of commonly used cancer cell lines. Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019) PubMed=31416301; DOI=10.1002/pros.23800 Koochekpour S., Maresh G.A., Katner A., Parker-Johnson K., Lee T.-J., Hebert F.E., Kao Y.S., Skinner J., Rayford W. Correction: Establishment and characterization of a primary androgen-responsive African-American prostate cancer cell line, E006AA. Prostate 2004;60(2):145-152. Prostate 79:815-815(2019) |
Cross-references |
Cell line collections |
ATCC; CRL-3277
|
Encyclopedic resources |
Wikidata; Q38514377
|
Entry history |
Entry creation | 05-Sep-2014 |
Last entry update | 21-Mar-2023 |
Version number | 13 |
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